Mytrex_F
Category
Mytrex_F Brand names, Mytrex_F Analogs
Mytrex_F Brand Names Mixture
No information avaliable
Mytrex_F Chemical_Formula
C47H75NO17
Mytrex_F RX_link
http://www.rxlist.com/cgi/generic2/nystat.htm
Mytrex_F fda sheet
Mytrex_F msds (material safety sheet)
Mytrex_F Synthesis Reference
No information avaliable
Mytrex_F Molecular Weight
926.09 g/mol
Mytrex_F Melting Point
160oC
Mytrex_F H2O Solubility
360 mg/L
Mytrex_F State
Solid
Mytrex_F LogP
-0.534
Mytrex_F Dosage Forms
Cream; Drops; Liquid; Ointment; Suspension; Tablet
Mytrex_F Indication
For treatment of cutaneous or mucocutaneous mycotic infections caused by Candida species
Mytrex_F Pharmacology
Nystatin is an antibiotic which is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi, including Candida albicans, C. parapsilosis, C. tropicalis, C. guilliermondi, C. pseudotropicalis, C. krusei, Torulopsis glabrata, Tricophyton rubrum, T. mentagrophytes. Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components. On repeated subculturing with increasing levels of nystatin, Candida albicans does not develop resistance to nystatin. Generally, resistance to nystatin does not develop during therapy. However, other species of Candida (C. tropicalis, C. guilliermondi, C. krusei, and C. stellatoides) become quite resistant on treatment with nystatin and simultaneously become cross resistant to amphotericin as well. This resistance is lost when the antibiotic is removed. Nystatin exhibits no appreciable activity against bacteria, protozoa, or viruses.
Mytrex_F Absorption
Nystatin is not absorbed from intact skin or mucous membrane
Mytrex_F Toxicity
No information avaliable
Mytrex_F Patient Information
No information avaliable
Mytrex_F Organisms Affected
Fungi
