Nysert
Category
Nysert Brand names, Nysert Analogs
Nysert Brand Names Mixture
No information avaliable
Nysert Chemical_Formula
C47H75NO17
Nysert RX_link
http://www.rxlist.com/cgi/generic2/nystat.htm
Nysert fda sheet
Nysert msds (material safety sheet)
Nysert Synthesis Reference
No information avaliable
Nysert Molecular Weight
926.09 g/mol
Nysert Melting Point
160oC
Nysert H2O Solubility
360 mg/L
Nysert State
Solid
Nysert LogP
-0.534
Nysert Dosage Forms
Cream; Drops; Liquid; Ointment; Suspension; Tablet
Nysert Indication
For treatment of cutaneous or mucocutaneous mycotic infections caused by Candida species
Nysert Pharmacology
Nystatin is an antibiotic which is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi, including Candida albicans, C. parapsilosis, C. tropicalis, C. guilliermondi, C. pseudotropicalis, C. krusei, Torulopsis glabrata, Tricophyton rubrum, T. mentagrophytes. Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components. On repeated subculturing with increasing levels of nystatin, Candida albicans does not develop resistance to nystatin. Generally, resistance to nystatin does not develop during therapy. However, other species of Candida (C. tropicalis, C. guilliermondi, C. krusei, and C. stellatoides) become quite resistant on treatment with nystatin and simultaneously become cross resistant to amphotericin as well. This resistance is lost when the antibiotic is removed. Nystatin exhibits no appreciable activity against bacteria, protozoa, or viruses.
Nysert Absorption
Nystatin is not absorbed from intact skin or mucous membrane
Nysert Toxicity
No information avaliable
Nysert Patient Information
No information avaliable
Nysert Organisms Affected
Fungi
