Dextrorazoxane
Category
Dextrorazoxane Brand names, Dextrorazoxane Analogs
Dextrorazoxane Brand Names Mixture
Dextrorazoxane Chemical_Formula
C11H16N4O4
Dextrorazoxane RX_link
http://www.rxlist.com/cgi/generic2/dexrazoxane.htm
Dextrorazoxane fda sheet
Dextrorazoxane msds (material safety sheet)
Dextrorazoxane Synthesis Reference
No information avaliable
Dextrorazoxane Molecular Weight
268.269 g/mol
Dextrorazoxane Melting Point
191 - 197 oC
Dextrorazoxane H2O Solubility
Sparingly soluble
Dextrorazoxane State
Solid
Dextrorazoxane LogP
-2.135
Dextrorazoxane Dosage Forms
Liquid; Powder for solution
Dextrorazoxane Indication
For reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer.
Dextrorazoxane Pharmacology
Dexrazoxane is a cardioprotective agent for use in conjunction with doxorubicin indicated for reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin dose.
Dextrorazoxane Absorption
IV administration results in complete bioavailability.
Dextrorazoxane side effects and Toxicity
Intraperitoneal, mouse LD10 = 500 mg/kg. Intravenous, dog LD10 = 2 gm/kg.
Dextrorazoxane Patient Information
No information avaliable
Dextrorazoxane Organisms Affected
Humans and other mammals
