Desrazoxane
Category
Desrazoxane Brand names, Desrazoxane Analogs
Desrazoxane Brand Names Mixture
Desrazoxane Chemical_Formula
C11H16N4O4
Desrazoxane RX_link
http://www.rxlist.com/cgi/generic2/dexrazoxane.htm
Desrazoxane fda sheet
Desrazoxane msds (material safety sheet)
Desrazoxane Synthesis Reference
No information avaliable
Desrazoxane Molecular Weight
268.269 g/mol
Desrazoxane Melting Point
191 - 197 oC
Desrazoxane H2O Solubility
Sparingly soluble
Desrazoxane State
Solid
Desrazoxane LogP
-2.135
Desrazoxane Dosage Forms
Liquid; Powder for solution
Desrazoxane Indication
For reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer.
Desrazoxane Pharmacology
Dexrazoxane is a cardioprotective agent for use in conjunction with doxorubicin indicated for reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin dose.
Desrazoxane Absorption
IV administration results in complete bioavailability.
Desrazoxane side effects and Toxicity
Intraperitoneal, mouse LD10 = 500 mg/kg. Intravenous, dog LD10 = 2 gm/kg.
Desrazoxane Patient Information
No information avaliable
Desrazoxane Organisms Affected
Humans and other mammals
