Categoria
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Nombres de marca,
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Analogos
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Marca los nombres de mezcla
LOPRESSOR HCT
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Formula quimica
C15H25NO3
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RX enlace
http://www.rxlist.com/cgi/generic/metopxl.htm
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FDA hoja
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MSDS (hoja de seguridad de materiales)
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Sintesis de referencia
AE Brandstorm et al., Patente de EE.UU.. 3,873,600 (1975)
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Peso molecular
267.364 g/mol
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Punto de fusion
120 oC (tartarate salt)
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H2O Solubilidad
16,9 mg / ml
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Estado
Solid
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LogP
2.477
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Formas de dosificacion
Tableta
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Indicacion
Para el tratamiento de la hipertensión y la angina de pecho.
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Farmacologia
Metoprolol, un antagonista competitivo, adrenérgicos beta1-selectivo (cardioselectivo), es similar a atenolol en su moderada solubilidad en lípidos, la falta de actividad simpaticomimética intrínseca (ISA), y la membrana débil estabilización de la actividad (MSA).
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Absorcion
Rápida y completa, el 50%
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Toxicidad
DL50 = 5500 mg / kg (por vía oral en ratas), efectos tóxicos incluyen bradicardia, hipotensión, broncoespasmo e insuficiencia cardiaca. DL50 = 2090 mg / kg (por vía oral en ratones)
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Informacion de Pacientes
Metoprolol succinate is used to treat high blood pressure alone or in combination with other medications. This
medication can also be used to treat a heart condition called angina. This particular formulation is an extended
release product, meaning it can be taken once a day. This medication should be taken as directed, with a meal or
right after a meal. The tablets should not be broken or crushed. Do not take a double dose if a dose is missed. This
medication should not be stopped abruptly; it should be discontinued slowly over time. If you are taking this
medication for high blood pressure, make sure to have your blood pressure checked regularly. If you ever have trouble
breathing, call your physician immediately. The most common adverse effects are dizziness and tiredness. It is
important to inform all your healthcare providers that you are taking this medication, especially before any
surgeries or procedures.
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Organismos afectados
Humanos y otros mamíferos