Categoria
Metoprolol
Nombres de marca,
Metoprolol
Analogos
Metoprolol
Marca los nombres de mezcla
LOPRESSOR HCT
Metoprolol
Formula quimica
C15H25NO3
Metoprolol
RX enlace
http://www.rxlist.com/cgi/generic/metopxl.htm
Metoprolol
FDA hoja
Metoprolol
MSDS (hoja de seguridad de materiales)
Metoprolol
Sintesis de referencia
AE Brandstorm et al., Patente de EE.UU.. 3,873,600 (1975)
Metoprolol
Peso molecular
267.364 g/mol
Metoprolol
Punto de fusion
120 oC (tartarate salt)
Metoprolol
H2O Solubilidad
16,9 mg / ml
Metoprolol
Estado
Solid
Metoprolol
LogP
2.477
Metoprolol
Formas de dosificacion
Tableta
Metoprolol
Indicacion
Para el tratamiento de la hipertensión y la angina de pecho.
Metoprolol
Farmacologia
Metoprolol, un antagonista competitivo, adrenérgicos beta1-selectivo (cardioselectivo), es similar a atenolol en su moderada solubilidad en lípidos, la falta de actividad simpaticomimética intrínseca (ISA), y la membrana débil estabilización de la actividad (MSA).
Metoprolol
Absorcion
Rápida y completa, el 50%
Metoprolol
Toxicidad
DL50 = 5500 mg / kg (por vía oral en ratas), efectos tóxicos incluyen bradicardia, hipotensión, broncoespasmo e insuficiencia cardiaca. DL50 = 2090 mg / kg (por vía oral en ratones)
Metoprolol
Informacion de Pacientes
Metoprolol succinate is used to treat high blood pressure alone or in combination with other medications. This
medication can also be used to treat a heart condition called angina. This particular formulation is an extended
release product, meaning it can be taken once a day. This medication should be taken as directed, with a meal or
right after a meal. The tablets should not be broken or crushed. Do not take a double dose if a dose is missed. This
medication should not be stopped abruptly; it should be discontinued slowly over time. If you are taking this
medication for high blood pressure, make sure to have your blood pressure checked regularly. If you ever have trouble
breathing, call your physician immediately. The most common adverse effects are dizziness and tiredness. It is
important to inform all your healthcare providers that you are taking this medication, especially before any
surgeries or procedures.
Metoprolol
Organismos afectados
Humanos y otros mamíferos