Zinat

Zinat Brand names, Zinat Analogs

Zinat Brand Names Mixture

No information avaliable

Zinat Chemical_Formula

C₁₆H₁₆N₄O₈S

Zinat RX_link

http://www.rxlist.com/cgi/generic/cefurox.htm

Zinat fda sheet

Zinat FDA

Zinat msds (material safety sheet)

Zinat MSDS

Zinat Synthesis Reference

M. C. Cook et al., U.S. Pat. 4,267,320 (1977)

Zinat Molecular Weight

424.386 g/mol

Zinat Melting Point

218-225 ^oC

Zinat H₂O Solubility

Freely soluble as sodium salt (145 mg/L)

Zinat State

Solid

Zinat LogP

-0.921

Zinat Dosage Forms

Powder; Powder for oral suspension; Tablet (125, 250, or 500 mg)

Zinat Indication

For the treatment of many different types of bacterial infections such as bronchitis, sinusitis, tonsillitis, ear infections, skin infections, gonorrhea, and urinary tract infections.

Zinat Pharmacology

Cefuroxime is a β-lactam type antibiotic. More specifically, it is a second-generation cephalosporin. Cephalosporins work the same way as penicillins: they interfere with the peptidoglycan synthesis of the bacterial wall by inhibiting the final transpeptidation needed for the cross-links. This effect is bactericidal. Cefuroxime is effective against the following organisms: Aerobic Gram-positive Microorganisms: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes. Aerobic Gram-negative Microorganisms: Escherichia coli, Haemophilus influenzae (including beta-lactamase-producing strains), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (including beta-lactamase-producing strains), Neisseria gonorrhoeae (including beta-lactamase-producing strains). Spirochetes: Borrelia burgdorferi.

Zinat Absorption

Absorbed from the gastrointestinal tract. Absorption is greater when taken after food (absolute bioavailability increases from 37% to 52%).

Zinat side effects and Toxicity

Allergic reactions might be expected, including rash, nasal congestion, cough, dry throat, eye irritation, or anaphylactic shock. Overdosage of cephalosporins can cause cerebral irritation leading to convulsions.

Zinat Patient Information

Patients should be counseled that antibacterial drugs including Cefuroxime for Injection USP and Dextrose Injection USP should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When Cefuroxime for Injection USP and Dextrose Injection USP is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by Cefuroxime for Injection USP and Dextrose Injection USP or other antibacterial drugs in the future.

Zinat Organisms Affected

Enteric bacteria and other eubacteria