Zinat

GLAXO INC -- CEFUROXIME SODIUM -- 6505-01-209-1205
=====================  Product Identification  =====================

Product ID:CEFUROXIME SODIUM
MSDS Date:11/12/1990
FSC:6505
NIIN:01-209-1205
MSDS Number: BWMHG
=== Responsible Party ===
Company Name:GLAXO INC
Address:5 MOORE DR
City:RESEARCH TRIANGLE PARK
State:NC
ZIP:27709
Country:US
Info Phone Num:919-248-2354
Emergency Phone Num:919-248-2100/2700
Preparer's Name:DIRECTOR, ENVIRON SAFETY
CAGE:34006
=== Contractor Identification ===
Company Name:GLAXO WELLCOME INC.
Address:5 MOORE DR
Box:13398
City:DURHAM
State:NC
ZIP:27709
Country:US
Phone:919-248-2100
CAGE:34006

=============  Composition/Information on Ingredients  =============

Ingred Name:CEFUROXIME SODIUM
CAS:56238-63-2
RTECS #:XI0330000
Fraction by Wt: 100%
Other REC Limits:0.1 MG/M3 (MFR)

=====================  Hazards Identification  =====================

Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:ZINACEF IS A CEPHALOSPORIN ANTIBIOTIC
    USED TO TREAT BACTERIAL INGECTIONS DUE TO SUSCEPTIBLE ORGANISMS.
    ACUTE DUST EXPOSURE MAY CAUSE MILD TO SEVERE ALLERGIC REACTIONS IN
    SENSITIVE INDIVIDUALS. THERE I S NO RECORDED FATAL ANAPHYLAXIS, BUT
    ITIS A POSSIBILITY. MAY BE A SKIN SENSITIZER.
Explanation of Carcinogenicity:THERE IS NO PUBLISHED EVIDENCE THAT THE
    COMPOUND IS CARCINOGENIC OR TERATOGENIC. WAS NEGATIVE ON THE
    MUTAGENIC AMES TEST
Effects of Overexposure:INHALED:RESPIRATORY IRRITATION,ITCHY SKIN
    RASHES,HIVES,RUNNY/STUFFY NOSE,CHEST TIGHTNESS,SWELLING & DIFFICULT
    BREATHING. SKIN:SENSITIZER. RED ITCHY SKIN RASH AFTER REPEATED
    CONTACT.
Medical Cond Aggravated by Exposure:ALLERGIC REACTIONS MAY OCCUR IN
    INDIVIDUALS SENSITIVE TO CEPHALOSPORINS, PENICILLLINS OR RELATED
    COMPOUNDS.

=======================  First Aid Measures  =======================

First Aid:EYE:FLUSH THOROUGHLY W/LARGE AMOUNT OF WATER. GET MEDICAL
    ATTENTION. SKIN:REMOVE CONTAMINATED CLOTHING & WASH W/SOAP & WATER.
    INHALED:REMOVE VICTIM TO FRESH AIR. IF BREATHING IS DIFFICULT OR
    CEASES, G IVE OXYGEN OR CPR. GET MEDICAL ATTENTION. INGESTED:RINSE
    MOUTH WITH WATER. GET MEDICAL ATTENTION.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:WATER SPRAY, FOAM, MULTI-PURPOSE DRY CHEMICAL.
Fire Fighting Procedures:WEAR FULL PROTECTIVE CLOTHING AND USE SELF
    CONTAINED BREATHING APPARATUS.
Unusual Fire/Explosion Hazard:AS WITH ANY ORGANIC DUST, THERE IS
    POTENTIAL FOR EXPLOSION WHEN SUSPENDED IN AIR IN HIGH
    CONCENTRATIONS.

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR FULL PROTECTIVE EQUIPMENT. AVOID BODY
    CONTACT AND/OR BREATHING DUST. COLLECT SPILLAGE BY CAREFULLLY
    SWEEPING OR VACUUMING WITH HEPA FILTEREDVACUUM & PLACE IN LABELED,
    SEALED CONTAINER FOR REUSE O R DISPOSAL. WASH AREA AFTER VACUUMING.
Neutralizing Agent:MFR GAVE NO INFORMATION ON MSDS.

======================	Handling and Storage  ======================

Handling and Storage Precautions:USE STORAGE PRACTICES THAT WILL
    MINIMIZE GENERATION OF DUST.
Other Precautions:SPECIAL CARE SHOULD BE TAKEN TO INSURE THAT
    CONTAMINATED CLOTHING & EQUIPMENT ARE PROPERLY CLEANED AFTER USE.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:WEAR RESPIRATORY PROTECTIVE EQUIPMENT WHEN
    EXPOSED TO DUST LEVELS THAT EXCEED THE ESTIMATED SAGE WORKING LEVEL
    (MFR'S). FOLLOW NIOSH, ANSI Z88.2, AND THE RESPIRATORY EQUIPMENT
    MANUFACTURER'S RECOMMEND ATIONS.
Ventilation:PROVIDE LOCAL EXHAUST VENTILATION SYSTEM AT THE SOURCE OF
    DUST GENERATION.
Protective Gloves:WEAR PROTECTIVE GLOVES AT ALL TIMES.
Eye Protection:PROTECT EYE FROM DUST.
Other Protective Equipment:A PROTECTIVE OUTER GARMENT IS ADEQUATE FOR
    LOW DUST EXPOSURE. FOR HIGH EXPOSURE, WEAR WEAR FULL BODY
    PROTECTION.
Work Hygienic Practices:ALL SKIN CONTACT SHOULD BE AVOIDED. EMPLOYEES
    EXPOSED TO DUST SHOULD CHANGE CLOTHES & SHOWER AT END OF WORK
    ASSIGNMENT.
Supplemental Safety and Health
NONE

==================  Physical/Chemical Properties  ==================

HCC:N1
NRC/State Lic Num:NONE
Melt/Freeze Pt:M.P/F.P Text:420F,216C
Solubility in Water:15% W/V
Appearance and Odor:WHITE TO CREAMY WHITE POWDER, ODOR NOT LISTED

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
NO KNOWN INCOMPATIBILITIES.
Stability Condition to Avoid:SLIGHTLY UNSTABLE IN AIR & WILL SLOWLY
    DECOMPOSE. THE MATERIAL SHOULD BE PROTECTED FROM LIGHT AND STORED
    UNDER NITROGEN.
Hazardous Decomposition Products:THERMAL DECOMPOSITION PRODUCTS INCLUDE
    TOXIC & CORROSIVE OXIDES OF NITROGEN AND SULFUR.

====================  Disposal Considerations  ====================

Waste Disposal Methods:INCINERATE AT AN APPROVED FACILITY I/A/W
    FEDERAL, STATE & LOCAL REGULATIONS.

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