Kefzol

Kefzol Brand names, Kefzol Analogs

Kefzol Brand Names Mixture

No information avaliable

Kefzol Chemical_Formula

C₁₆H₁₆N₄O₈S

Kefzol RX_link

http://www.rxlist.com/cgi/generic/cefurox.htm

Kefzol fda sheet

Kefzol FDA

Kefzol msds (material safety sheet)

Kefzol MSDS

Kefzol Synthesis Reference

M. C. Cook et al., U.S. Pat. 4,267,320 (1977)

Kefzol Molecular Weight

424.386 g/mol

Kefzol Melting Point

218-225 ^oC

Kefzol H₂O Solubility

Freely soluble as sodium salt (145 mg/L)

Kefzol State

Solid

Kefzol LogP

-0.921

Kefzol Dosage Forms

Powder; Powder for oral suspension; Tablet (125, 250, or 500 mg)

Kefzol Indication

For the treatment of many different types of bacterial infections such as bronchitis, sinusitis, tonsillitis, ear infections, skin infections, gonorrhea, and urinary tract infections.

Kefzol Pharmacology

Cefuroxime is a β-lactam type antibiotic. More specifically, it is a second-generation cephalosporin. Cephalosporins work the same way as penicillins: they interfere with the peptidoglycan synthesis of the bacterial wall by inhibiting the final transpeptidation needed for the cross-links. This effect is bactericidal. Cefuroxime is effective against the following organisms: Aerobic Gram-positive Microorganisms: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes. Aerobic Gram-negative Microorganisms: Escherichia coli, Haemophilus influenzae (including beta-lactamase-producing strains), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (including beta-lactamase-producing strains), Neisseria gonorrhoeae (including beta-lactamase-producing strains). Spirochetes: Borrelia burgdorferi.

Kefzol Absorption

Absorbed from the gastrointestinal tract. Absorption is greater when taken after food (absolute bioavailability increases from 37% to 52%).

Kefzol side effects and Toxicity

Allergic reactions might be expected, including rash, nasal congestion, cough, dry throat, eye irritation, or anaphylactic shock. Overdosage of cephalosporins can cause cerebral irritation leading to convulsions.

Kefzol Patient Information

Patients should be counseled that antibacterial drugs including Cefuroxime for Injection USP and Dextrose Injection USP should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When Cefuroxime for Injection USP and Dextrose Injection USP is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by Cefuroxime for Injection USP and Dextrose Injection USP or other antibacterial drugs in the future.

Kefzol Organisms Affected

Enteric bacteria and other eubacteria