Rocephin

Rocephin Brand names, Rocephin Analogs

Rocephin Brand Names Mixture

No information avaliable

Rocephin Chemical_Formula

C₁₆H₁₆N₄O₈S

Rocephin RX_link

http://www.rxlist.com/cgi/generic/cefurox.htm

Rocephin fda sheet

Rocephin FDA

Rocephin msds (material safety sheet)

Rocephin MSDS

Rocephin Synthesis Reference

M. C. Cook et al., U.S. Pat. 4,267,320 (1977)

Rocephin Molecular Weight

424.386 g/mol

Rocephin Melting Point

218-225 ^oC

Rocephin H₂O Solubility

Freely soluble as sodium salt (145 mg/L)

Rocephin State

Solid

Rocephin LogP

-0.921

Rocephin Dosage Forms

Powder; Powder for oral suspension; Tablet (125, 250, or 500 mg)

Rocephin Indication

For the treatment of many different types of bacterial infections such as bronchitis, sinusitis, tonsillitis, ear infections, skin infections, gonorrhea, and urinary tract infections.

Rocephin Pharmacology

Cefuroxime is a β-lactam type antibiotic. More specifically, it is a second-generation cephalosporin. Cephalosporins work the same way as penicillins: they interfere with the peptidoglycan synthesis of the bacterial wall by inhibiting the final transpeptidation needed for the cross-links. This effect is bactericidal. Cefuroxime is effective against the following organisms: Aerobic Gram-positive Microorganisms: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes. Aerobic Gram-negative Microorganisms: Escherichia coli, Haemophilus influenzae (including beta-lactamase-producing strains), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (including beta-lactamase-producing strains), Neisseria gonorrhoeae (including beta-lactamase-producing strains). Spirochetes: Borrelia burgdorferi.

Rocephin Absorption

Absorbed from the gastrointestinal tract. Absorption is greater when taken after food (absolute bioavailability increases from 37% to 52%).

Rocephin side effects and Toxicity

Allergic reactions might be expected, including rash, nasal congestion, cough, dry throat, eye irritation, or anaphylactic shock. Overdosage of cephalosporins can cause cerebral irritation leading to convulsions.

Rocephin Patient Information

Patients should be counseled that antibacterial drugs including Cefuroxime for Injection USP and Dextrose Injection USP should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When Cefuroxime for Injection USP and Dextrose Injection USP is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by Cefuroxime for Injection USP and Dextrose Injection USP or other antibacterial drugs in the future.

Rocephin Organisms Affected

Enteric bacteria and other eubacteria