Tolterodine
Tolterodine Brand names, Tolterodine Analogs
Tolterodine Brand Names Mixture
- No information avaliable
Tolterodine Chemical_Formula
C22H31NO
Tolterodine RX_link
http://www.rxlist.com/cgi/generic2/tolter.htm
Tolterodine fda sheet
Tolterodine msds (material safety sheet)
Tolterodine Synthesis Reference
No information avaliable
Tolterodine Molecular Weight
325.488 g/mol
Tolterodine Melting Point
No information avaliable
Tolterodine H2O Solubility
No information avaliable
Tolterodine State
Solid
Tolterodine LogP
6.076
Tolterodine Dosage Forms
Capsule (sustained-release)
Tolterodine Indication
For the treatment of overactive bladder (with symptoms of urinary frequency, urgency, or urge incontinence).
Tolterodine Pharmacology
Tolterodine is a competitive muscarinic receptor antagonist. Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors. After oral administration, tolterodine is metabolized in the liver, resulting in the formation of the 5-hydroxymethyl derivative, a major pharmacologically active metabolite. The 5-hydroxymethyl metabolite, which exhibits an antimuscarinic activity similar to that of tolterodine, contributes significantly to the therapeutic effect. Both tolterodine and the 5-hydroxymethyl metabolite exhibit a high specificity for muscarinic receptors, since both show negligible activity or affinity for other neurotransmitter receptors and other potential cellular targets, such as calcium channels. Tolterodine has a pronounced effect on bladder function. The main effects of tolterodine are an increase in residual urine, reflecting an incomplete emptying of the bladder, and a decrease in detrusor pressure, consistent with an antimuscarinic action on the lower urinary tract.
Tolterodine Absorption
No information avaliable
Tolterodine side effects and Toxicity
No information avaliable
Tolterodine Patient Information
No information avaliable
Tolterodine Organisms Affected
Humans and other mammals
