Tolterondine Tartrate
Tolterondine Tartrate Brand names, Tolterondine Tartrate Analogs
Tolterondine Tartrate Brand Names Mixture
- No information avaliable
Tolterondine Tartrate Chemical_Formula
C22H31NO
Tolterondine Tartrate RX_link
http://www.rxlist.com/cgi/generic2/tolter.htm
Tolterondine Tartrate fda sheet
Tolterondine Tartrate msds (material safety sheet)
Tolterondine Tartrate Synthesis Reference
No information avaliable
Tolterondine Tartrate Molecular Weight
325.488 g/mol
Tolterondine Tartrate Melting Point
No information avaliable
Tolterondine Tartrate H2O Solubility
No information avaliable
Tolterondine Tartrate State
Solid
Tolterondine Tartrate LogP
6.076
Tolterondine Tartrate Dosage Forms
Capsule (sustained-release)
Tolterondine Tartrate Indication
For the treatment of overactive bladder (with symptoms of urinary frequency, urgency, or urge incontinence).
Tolterondine Tartrate Pharmacology
Tolterodine is a competitive muscarinic receptor antagonist. Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors. After oral administration, tolterodine is metabolized in the liver, resulting in the formation of the 5-hydroxymethyl derivative, a major pharmacologically active metabolite. The 5-hydroxymethyl metabolite, which exhibits an antimuscarinic activity similar to that of tolterodine, contributes significantly to the therapeutic effect. Both tolterodine and the 5-hydroxymethyl metabolite exhibit a high specificity for muscarinic receptors, since both show negligible activity or affinity for other neurotransmitter receptors and other potential cellular targets, such as calcium channels. Tolterodine has a pronounced effect on bladder function. The main effects of tolterodine are an increase in residual urine, reflecting an incomplete emptying of the bladder, and a decrease in detrusor pressure, consistent with an antimuscarinic action on the lower urinary tract.
Tolterondine Tartrate Absorption
No information avaliable
Tolterondine Tartrate side effects and Toxicity
No information avaliable
Tolterondine Tartrate Patient Information
No information avaliable
Tolterondine Tartrate Organisms Affected
Humans and other mammals
