Tolterodinum [Inn-Latin] en es it fr

Tolterodinum [Inn-Latin] Brand names, Tolterodinum [Inn-Latin] Analogs

Tolterodinum [Inn-Latin] Brand Names Mixture

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Tolterodinum [Inn-Latin] Chemical_Formula


Tolterodinum [Inn-Latin] RX_link

Tolterodinum [Inn-Latin] fda sheet

Tolterodinum_[Inn-Latin] FDA

Tolterodinum [Inn-Latin] msds (material safety sheet)

Tolterodinum [Inn-Latin] Synthesis Reference

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Tolterodinum [Inn-Latin] Molecular Weight

325.488 g/mol

Tolterodinum [Inn-Latin] Melting Point

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Tolterodinum [Inn-Latin] H2O Solubility

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Tolterodinum [Inn-Latin] State


Tolterodinum [Inn-Latin] LogP


Tolterodinum [Inn-Latin] Dosage Forms

Capsule (sustained-release)

Tolterodinum [Inn-Latin] Indication

For the treatment of overactive bladder (with symptoms of urinary frequency, urgency, or urge incontinence).

Tolterodinum [Inn-Latin] Pharmacology

Tolterodine is a competitive muscarinic receptor antagonist. Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors. After oral administration, tolterodine is metabolized in the liver, resulting in the formation of the 5-hydroxymethyl derivative, a major pharmacologically active metabolite. The 5-hydroxymethyl metabolite, which exhibits an antimuscarinic activity similar to that of tolterodine, contributes significantly to the therapeutic effect. Both tolterodine and the 5-hydroxymethyl metabolite exhibit a high specificity for muscarinic receptors, since both show negligible activity or affinity for other neurotransmitter receptors and other potential cellular targets, such as calcium channels. Tolterodine has a pronounced effect on bladder function. The main effects of tolterodine are an increase in residual urine, reflecting an incomplete emptying of the bladder, and a decrease in detrusor pressure, consistent with an antimuscarinic action on the lower urinary tract.

Tolterodinum [Inn-Latin] Absorption

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Tolterodinum [Inn-Latin] side effects and Toxicity

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Tolterodinum [Inn-Latin] Patient Information

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Tolterodinum [Inn-Latin] Organisms Affected

Humans and other mammals