Tolterodina [Inn-Spanish]

• Antispasmodics
• Anti-Incontinence Agents
• Genitourinary Smooth Muscle Relaxants
• ATC:G04BD07

• Detrol
• Detrol LA
• Tolterodina [Inn-Spanish]
• Tolterodine L-Tartrate
• Tolterodine Tartrate
• Tolterodine [Inn]
• Tolterodinum [Inn-Latin]
• Tolterondine Tartrate

• No information avaliable

C₂₂H₃₁NO

http://www.rxlist.com/cgi/generic2/tolter.htm

Tolterodina_[Inn-Spanish] FDA

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325.488 g/mol

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Solid

6.076

Capsule (sustained-release)

For the treatment of overactive bladder (with symptoms of urinary frequency, urgency, or urge incontinence).

Tolterodine is a competitive muscarinic receptor antagonist. Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors. After oral administration, tolterodine is metabolized in the liver, resulting in the formation of the 5-hydroxymethyl derivative, a major pharmacologically active metabolite. The 5-hydroxymethyl metabolite, which exhibits an antimuscarinic activity similar to that of tolterodine, contributes significantly to the therapeutic effect. Both tolterodine and the 5-hydroxymethyl metabolite exhibit a high specificity for muscarinic receptors, since both show negligible activity or affinity for other neurotransmitter receptors and other potential cellular targets, such as calcium channels. Tolterodine has a pronounced effect on bladder function. The main effects of tolterodine are an increase in residual urine, reflecting an incomplete emptying of the bladder, and a decrease in detrusor pressure, consistent with an antimuscarinic action on the lower urinary tract.

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Humans and other mammals