PharmacyCodes



Tolterodina [Inn-Spanish] en es it fr

Tolterodina [Inn-Spanish] Brand names, Tolterodina [Inn-Spanish] Analogs

Tolterodina [Inn-Spanish] Brand Names Mixture

  • No information avaliable

Tolterodina [Inn-Spanish] Chemical_Formula

C22H31NO

Tolterodina [Inn-Spanish] RX_link

http://www.rxlist.com/cgi/generic2/tolter.htm

Tolterodina [Inn-Spanish] fda sheet

Tolterodina_[Inn-Spanish] FDA

Tolterodina [Inn-Spanish] msds (material safety sheet)

Tolterodina [Inn-Spanish] Synthesis Reference

No information avaliable

Tolterodina [Inn-Spanish] Molecular Weight

325.488 g/mol

Tolterodina [Inn-Spanish] Melting Point

No information avaliable

Tolterodina [Inn-Spanish] H2O Solubility

No information avaliable

Tolterodina [Inn-Spanish] State

Solid

Tolterodina [Inn-Spanish] LogP

6.076

Tolterodina [Inn-Spanish] Dosage Forms

Capsule (sustained-release)

Tolterodina [Inn-Spanish] Indication

For the treatment of overactive bladder (with symptoms of urinary frequency, urgency, or urge incontinence).

Tolterodina [Inn-Spanish] Pharmacology

Tolterodine is a competitive muscarinic receptor antagonist. Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors. After oral administration, tolterodine is metabolized in the liver, resulting in the formation of the 5-hydroxymethyl derivative, a major pharmacologically active metabolite. The 5-hydroxymethyl metabolite, which exhibits an antimuscarinic activity similar to that of tolterodine, contributes significantly to the therapeutic effect. Both tolterodine and the 5-hydroxymethyl metabolite exhibit a high specificity for muscarinic receptors, since both show negligible activity or affinity for other neurotransmitter receptors and other potential cellular targets, such as calcium channels. Tolterodine has a pronounced effect on bladder function. The main effects of tolterodine are an increase in residual urine, reflecting an incomplete emptying of the bladder, and a decrease in detrusor pressure, consistent with an antimuscarinic action on the lower urinary tract.

Tolterodina [Inn-Spanish] Absorption

No information avaliable

Tolterodina [Inn-Spanish] side effects and Toxicity

No information avaliable

Tolterodina [Inn-Spanish] Patient Information

No information avaliable

Tolterodina [Inn-Spanish] Organisms Affected

Humans and other mammals