Tiludronate disodium
Tiludronate disodium Brand names, Tiludronate disodium Analogs
Tiludronate disodium Brand Names Mixture
- No information avaliable
Tiludronate disodium Chemical_Formula
C15H15NO3
Tiludronate disodium RX_link
http://www.rxlist.com/cgi/generic2/tolmetin.htm
Tiludronate disodium fda sheet
Tiludronate disodium msds (material safety sheet)
Tiludronate disodium Synthesis Reference
No information avaliable
Tiludronate disodium Molecular Weight
257.285 g/mol
Tiludronate disodium Melting Point
156 oC
Tiludronate disodium H2O Solubility
222 mg/L
Tiludronate disodium State
Solid
Tiludronate disodium LogP
2.469
Tiludronate disodium Dosage Forms
Tablet (oral, equivalent to 200 mg or 600 mg of tolmetin); Capsule (oral, equivalent to 400 mg of tolmetin)
Tiludronate disodium Indication
For the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis, including the treatment of acute flares long-term management. Also for treatment of juvenile rheumatoid arthritis.
Tiludronate disodium Pharmacology
Tolmetin is a nonsteroidal anti-inflammatory agent. Studies in animals have shown tolmetin to possess anti-inflammatory, analgesic and antipyretic activity. In the rat, tolmetin prevents the development of experimentally induced polyarthritis and also decreases established inflammation. In patients with either rheumatoid arthritis or osteaoarthritis, tolmetin is as effective as aspirin and indomethacin in controlling disease activity, but the frequency of the milder gastrointestinal adverse effects and tinnitus was less than in aspirin-treated patients, and the incidence of central nervous system adverse effects was less than in indomethacin-treated patients. In patients with juvenile rheumatoid arthritis, tolmetin is as effective as aspirin in controlling disease activity, with a similar incidence of adverse reactions. tolmetin has produced additional therapeutic benefit when added to a regimen of gold salts and, to a lesser extent, with corticosteroids. Tolmetin should not be used in conjunction with salicylates since greater benefit from the combination is not likely, but the potential for adverse reactions is increased.
Tiludronate disodium Absorption
Rapidly and almost completely absorbed with peak plasma levels being reached within 30-60 minutes after an oral therapeutic dose.
Tiludronate disodium side effects and Toxicity
Symptoms of overdose include lethargy, drowsiness, nausea, vomiting, and epigastric pain.
Tiludronate disodium Patient Information
Tiludronate disodium Organisms Affected
Humans and other mammals
