Tiludronate disodium en es it fr

Tiludronate disodium Brand names, Tiludronate disodium Analogs

Tiludronate disodium Brand Names Mixture

  • No information avaliable

Tiludronate disodium Chemical_Formula


Tiludronate disodium RX_link


Tiludronate disodium fda sheet

Tiludronate disodium msds (material safety sheet)

Tiludronate_disodium MSDS

Tiludronate disodium Synthesis Reference

No information avaliable

Tiludronate disodium Molecular Weight

257.285 g/mol

Tiludronate disodium Melting Point

156 oC

Tiludronate disodium H2O Solubility

222 mg/L

Tiludronate disodium State


Tiludronate disodium LogP


Tiludronate disodium Dosage Forms

Tablet (oral, equivalent to 200 mg or 600 mg of tolmetin); Capsule (oral, equivalent to 400 mg of tolmetin)

Tiludronate disodium Indication

For the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis, including the treatment of acute flares long-term management. Also for treatment of juvenile rheumatoid arthritis.

Tiludronate disodium Pharmacology

Tolmetin is a nonsteroidal anti-inflammatory agent. Studies in animals have shown tolmetin to possess anti-inflammatory, analgesic and antipyretic activity. In the rat, tolmetin prevents the development of experimentally induced polyarthritis and also decreases established inflammation. In patients with either rheumatoid arthritis or osteaoarthritis, tolmetin is as effective as aspirin and indomethacin in controlling disease activity, but the frequency of the milder gastrointestinal adverse effects and tinnitus was less than in aspirin-treated patients, and the incidence of central nervous system adverse effects was less than in indomethacin-treated patients. In patients with juvenile rheumatoid arthritis, tolmetin is as effective as aspirin in controlling disease activity, with a similar incidence of adverse reactions. tolmetin has produced additional therapeutic benefit when added to a regimen of gold salts and, to a lesser extent, with corticosteroids. Tolmetin should not be used in conjunction with salicylates since greater benefit from the combination is not likely, but the potential for adverse reactions is increased.

Tiludronate disodium Absorption

Rapidly and almost completely absorbed with peak plasma levels being reached within 30-60 minutes after an oral therapeutic dose.

Tiludronate disodium side effects and Toxicity

Symptoms of overdose include lethargy, drowsiness, nausea, vomiting, and epigastric pain.

Tiludronate disodium Patient Information

Tiludronate disodium Organisms Affected

Humans and other mammals