Tiludronic Acid Disodium Salt
Tiludronic Acid Disodium Salt Brand names, Tiludronic Acid Disodium Salt Analogs
Tiludronic Acid Disodium Salt Brand Names Mixture
- No information avaliable
Tiludronic Acid Disodium Salt Chemical_Formula
C15H15NO3
Tiludronic Acid Disodium Salt RX_link
http://www.rxlist.com/cgi/generic2/tolmetin.htm
Tiludronic Acid Disodium Salt fda sheet
Tiludronic Acid Disodium Salt msds (material safety sheet)
Tiludronic Acid Disodium Salt Synthesis Reference
No information avaliable
Tiludronic Acid Disodium Salt Molecular Weight
257.285 g/mol
Tiludronic Acid Disodium Salt Melting Point
156 oC
Tiludronic Acid Disodium Salt H2O Solubility
222 mg/L
Tiludronic Acid Disodium Salt State
Solid
Tiludronic Acid Disodium Salt LogP
2.469
Tiludronic Acid Disodium Salt Dosage Forms
Tablet (oral, equivalent to 200 mg or 600 mg of tolmetin); Capsule (oral, equivalent to 400 mg of tolmetin)
Tiludronic Acid Disodium Salt Indication
For the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis, including the treatment of acute flares long-term management. Also for treatment of juvenile rheumatoid arthritis.
Tiludronic Acid Disodium Salt Pharmacology
Tolmetin is a nonsteroidal anti-inflammatory agent. Studies in animals have shown tolmetin to possess anti-inflammatory, analgesic and antipyretic activity. In the rat, tolmetin prevents the development of experimentally induced polyarthritis and also decreases established inflammation. In patients with either rheumatoid arthritis or osteaoarthritis, tolmetin is as effective as aspirin and indomethacin in controlling disease activity, but the frequency of the milder gastrointestinal adverse effects and tinnitus was less than in aspirin-treated patients, and the incidence of central nervous system adverse effects was less than in indomethacin-treated patients. In patients with juvenile rheumatoid arthritis, tolmetin is as effective as aspirin in controlling disease activity, with a similar incidence of adverse reactions. tolmetin has produced additional therapeutic benefit when added to a regimen of gold salts and, to a lesser extent, with corticosteroids. Tolmetin should not be used in conjunction with salicylates since greater benefit from the combination is not likely, but the potential for adverse reactions is increased.
Tiludronic Acid Disodium Salt Absorption
Rapidly and almost completely absorbed with peak plasma levels being reached within 30-60 minutes after an oral therapeutic dose.
Tiludronic Acid Disodium Salt side effects and Toxicity
Symptoms of overdose include lethargy, drowsiness, nausea, vomiting, and epigastric pain.
Tiludronic Acid Disodium Salt Patient Information
Tiludronic Acid Disodium Salt Organisms Affected
Humans and other mammals
