Acidum tiludronicum
Brand names,
Acidum tiludronicum
Analogs
Acidum tiludronicum
Brand Names Mixture
Acidum tiludronicum
Chemical_Formula
C15H15NO3
Acidum tiludronicum
RX_link
http://www.rxlist.com/cgi/generic2/tolmetin.htm
Acidum tiludronicum
fda sheet
Acidum tiludronicum
msds (material safety sheet)
Acidum tiludronicum
Synthesis Reference
No information avaliable
Acidum tiludronicum
Molecular Weight
257.285 g/mol
Acidum tiludronicum
Melting Point
156 oC
Acidum tiludronicum
H2O Solubility
222 mg/L
Acidum tiludronicum
State
Solid
Acidum tiludronicum
LogP
2.469
Acidum tiludronicum
Dosage Forms
Tablet (oral, equivalent to 200 mg or 600 mg of tolmetin); Capsule (oral, equivalent to 400 mg of tolmetin)
Acidum tiludronicum
Indication
For the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis, including the treatment of acute flares long-term management. Also for treatment of juvenile rheumatoid arthritis.
Acidum tiludronicum
Pharmacology
Tolmetin is a nonsteroidal anti-inflammatory agent. Studies in animals have shown tolmetin to possess anti-inflammatory, analgesic and antipyretic activity. In the rat, tolmetin prevents the development of experimentally induced polyarthritis and also decreases established inflammation. In patients with either rheumatoid arthritis or osteaoarthritis, tolmetin is as effective as aspirin and indomethacin in controlling disease activity, but the frequency of the milder gastrointestinal adverse effects and tinnitus was less than in aspirin-treated patients, and the incidence of central nervous system adverse effects was less than in indomethacin-treated patients. In patients with juvenile rheumatoid arthritis, tolmetin is as effective as aspirin in controlling disease activity, with a similar incidence of adverse reactions. tolmetin has produced additional therapeutic benefit when added to a regimen of gold salts and, to a lesser extent, with corticosteroids. Tolmetin should not be used in conjunction with salicylates since greater benefit from the combination is not likely, but the potential for adverse reactions is increased.
Acidum tiludronicum
Absorption
Rapidly and almost completely absorbed with peak plasma levels being reached within 30-60 minutes after an oral therapeutic dose.
Acidum tiludronicum
side effects and Toxicity
Symptoms of overdose include lethargy, drowsiness, nausea, vomiting, and epigastric pain.
Acidum tiludronicum
Patient Information
Acidum tiludronicum
Organisms Affected
Humans and other mammals