Acide tiludronique [INN-French]

Acide tiludronique [INN-French] Brand names, Acide tiludronique [INN-French] Analogs

Acide tiludronique [INN-French] Brand Names Mixture

No information avaliable

Acide tiludronique [INN-French] Chemical_Formula

C₁₅H₁₅NO₃

Acide tiludronique [INN-French] RX_link

http://www.rxlist.com/cgi/generic2/tolmetin.htm

Acide tiludronique [INN-French] fda sheet

Acide tiludronique [INN-French] msds (material safety sheet)

Acide_tiludronique_[INN-French] MSDS

Acide tiludronique [INN-French] Synthesis Reference

No information avaliable

Acide tiludronique [INN-French] Molecular Weight

257.285 g/mol

Acide tiludronique [INN-French] Melting Point

156 ^oC

Acide tiludronique [INN-French] H₂O Solubility

222 mg/L

Acide tiludronique [INN-French] State

Solid

Acide tiludronique [INN-French] LogP

2.469

Acide tiludronique [INN-French] Dosage Forms

Tablet (oral, equivalent to 200 mg or 600 mg of tolmetin); Capsule (oral, equivalent to 400 mg of tolmetin)

Acide tiludronique [INN-French] Indication

For the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis, including the treatment of acute flares long-term management. Also for treatment of juvenile rheumatoid arthritis.

Acide tiludronique [INN-French] Pharmacology

Tolmetin is a nonsteroidal anti-inflammatory agent. Studies in animals have shown tolmetin to possess anti-inflammatory, analgesic and antipyretic activity. In the rat, tolmetin prevents the development of experimentally induced polyarthritis and also decreases established inflammation. In patients with either rheumatoid arthritis or osteaoarthritis, tolmetin is as effective as aspirin and indomethacin in controlling disease activity, but the frequency of the milder gastrointestinal adverse effects and tinnitus was less than in aspirin-treated patients, and the incidence of central nervous system adverse effects was less than in indomethacin-treated patients. In patients with juvenile rheumatoid arthritis, tolmetin is as effective as aspirin in controlling disease activity, with a similar incidence of adverse reactions. tolmetin has produced additional therapeutic benefit when added to a regimen of gold salts and, to a lesser extent, with corticosteroids. Tolmetin should not be used in conjunction with salicylates since greater benefit from the combination is not likely, but the potential for adverse reactions is increased.

Acide tiludronique [INN-French] Absorption

Rapidly and almost completely absorbed with peak plasma levels being reached within 30-60 minutes after an oral therapeutic dose.

Acide tiludronique [INN-French] side effects and Toxicity

Symptoms of overdose include lethargy, drowsiness, nausea, vomiting, and epigastric pain.

Acide tiludronique [INN-French] Patient Information

Acide tiludronique [INN-French] Organisms Affected

Humans and other mammals