Sular
Sular Brand names, Sular Analogs
Sular Brand Names Mixture
- No information avaliable
Sular Chemical_Formula
C20H24N2O6
Sular RX_link
http://www.rxlist.com/cgi/generic/nisoldipine.htm
Sular fda sheet
Sular msds (material safety sheet)
Sular Synthesis Reference
No information avaliable
Sular Molecular Weight
388.414 g/mol
Sular Melting Point
No information avaliable
Sular H2O Solubility
No information avaliable
Sular State
Solid
Sular LogP
3.475
Sular Dosage Forms
No information avaliable
Sular Indication
Hypertension
Sular Pharmacology
Nisoldipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Nisoldipine is similar to other peripheral vasodilators. Nisoldipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Sular Absorption
No information avaliable
Sular side effects and Toxicity
No information avaliable
Sular Patient Information
Sular Organisms Affected
Humans and other mammals
