Sudafed Decongestant
Brand names,
Sudafed Decongestant
Analogs
Sudafed Decongestant
Brand Names Mixture
Sudafed Decongestant
Chemical_Formula
C10H15NO
Sudafed Decongestant
RX_link
http://www.rxlist.com/cgi/generic/sudafed.htm
Sudafed Decongestant
fda sheet
Sudafed Decongestant
msds (material safety sheet)
Sudafed Decongestant
Synthesis Reference
No information avaliable
Sudafed Decongestant
Molecular Weight
165.232 g/mol
Sudafed Decongestant
Melting Point
117 - 118 oC
Sudafed Decongestant
H2O Solubility
7 mg/L
Sudafed Decongestant
State
Solid
Sudafed Decongestant
LogP
1.507
Sudafed Decongestant
Dosage Forms
Capsule (sustained-release); Tablet; Tablet (extended-release); Oral liquid; Nasal spray; Syrup
Sudafed Decongestant
Indication
For the treatment of nasal congestion, sinus congestion, Eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism.
Sudafed Decongestant
Pharmacology
Pseudoephedrine is a sympathomimetic agent, structurally similar to ephedrine, used to relieve nasal and sinus congestion and reduce air-travel-related otalgia in adults. The salts pseudoephedrine hydrochloride and pseudoephedrine sulfate are found in many over-the-counter preparations either as single-ingredient preparations, or more commonly in combination with antihistamines and/or paracetamol/ibuprofen. Unlike antihistamines, which modify the systemic histamine-mediated allergic response, pseudoephedrine only serves to relieve nasal congestion commonly associated with colds or allergies. The advantage of oral pseudoephedrine over topical nasal preparations, such as oxymetazoline, is that it does not cause rebound congestion (rhinitis medicamentosa).
Sudafed Decongestant
Absorption
Pseudoephedrine is readily and almost completely absorbed from the GI tract and there is no evidence of first-pass metabolism.
Sudafed Decongestant
side effects and Toxicity
Common adverse reactions include nervousness, restlessness, and insomnia. Rare adverse reactions include difficult/painful urination, dizziness/lightheadedness, heart palpitations, headache, increased sweating, nausea/vomiting, trembling, troubled breathing, unusual paleness, and weakness.
Sudafed Decongestant
Patient Information
Sudafed Decongestant
Organisms Affected
Humans and other mammals