Psi-Ephedrin
Brand names,
Psi-Ephedrin
Analogs
Psi-Ephedrin
Brand Names Mixture
Psi-Ephedrin
Chemical_Formula
C10H15NO
Psi-Ephedrin
RX_link
http://www.rxlist.com/cgi/generic/sudafed.htm
Psi-Ephedrin
fda sheet
Psi-Ephedrin
msds (material safety sheet)
Psi-Ephedrin
Synthesis Reference
No information avaliable
Psi-Ephedrin
Molecular Weight
165.232 g/mol
Psi-Ephedrin
Melting Point
117 - 118 oC
Psi-Ephedrin
H2O Solubility
7 mg/L
Psi-Ephedrin
State
Solid
Psi-Ephedrin
LogP
1.507
Psi-Ephedrin
Dosage Forms
Capsule (sustained-release); Tablet; Tablet (extended-release); Oral liquid; Nasal spray; Syrup
Psi-Ephedrin
Indication
For the treatment of nasal congestion, sinus congestion, Eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism.
Psi-Ephedrin
Pharmacology
Pseudoephedrine is a sympathomimetic agent, structurally similar to ephedrine, used to relieve nasal and sinus congestion and reduce air-travel-related otalgia in adults. The salts pseudoephedrine hydrochloride and pseudoephedrine sulfate are found in many over-the-counter preparations either as single-ingredient preparations, or more commonly in combination with antihistamines and/or paracetamol/ibuprofen. Unlike antihistamines, which modify the systemic histamine-mediated allergic response, pseudoephedrine only serves to relieve nasal congestion commonly associated with colds or allergies. The advantage of oral pseudoephedrine over topical nasal preparations, such as oxymetazoline, is that it does not cause rebound congestion (rhinitis medicamentosa).
Psi-Ephedrin
Absorption
Pseudoephedrine is readily and almost completely absorbed from the GI tract and there is no evidence of first-pass metabolism.
Psi-Ephedrin
side effects and Toxicity
Common adverse reactions include nervousness, restlessness, and insomnia. Rare adverse reactions include difficult/painful urination, dizziness/lightheadedness, heart palpitations, headache, increased sweating, nausea/vomiting, trembling, troubled breathing, unusual paleness, and weakness.
Psi-Ephedrin
Patient Information
Psi-Ephedrin
Organisms Affected
Humans and other mammals