Saquinavir
Saquinavir Brand names, Saquinavir Analogs
Saquinavir Brand Names Mixture
- No information avaliable
Saquinavir Chemical_Formula
C38H50N6O5
Saquinavir RX_link
http://www.rxlist.com/cgi/generic/saquin.htm
Saquinavir fda sheet
Saquinavir msds (material safety sheet)
Saquinavir Synthesis Reference
Parkes, Kevin E. B. et al., J. Org. Chem. 59(13) 3656-3664(1994)
Saquinavir Molecular Weight
670.841 g/mol
Saquinavir Melting Point
349.84 oC
Saquinavir H2O Solubility
Insoluble
Saquinavir State
Solid
Saquinavir LogP
3.645
Saquinavir Dosage Forms
Capsules
Saquinavir Indication
For the treatment of HIV-1 with advanced immunodeficiency together with antiretroviral nucleoside analogues.
Saquinavir Pharmacology
Saquinavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Saquinavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs.
Saquinavir Absorption
Absolute bioavailability averages 4%
Saquinavir side effects and Toxicity
Probably experience pain in the throat
Saquinavir Patient Information
Saquinavir Organisms Affected
Human immunodeficiency virus
