Saquinavir [Usan]

Saquinavir [Usan] Brand names, Saquinavir [Usan] Analogs

Saquinavir [Usan] Brand Names Mixture

No information avaliable

Saquinavir [Usan] Chemical_Formula

C₃₈H₅₀N₆O₅

Saquinavir [Usan] RX_link

http://www.rxlist.com/cgi/generic/saquin.htm

Saquinavir [Usan] fda sheet

Saquinavir_[Usan] FDA

Saquinavir [Usan] msds (material safety sheet)

Saquinavir [Usan] Synthesis Reference

Parkes, Kevin E. B. et al., J. Org. Chem. 59(13) 3656-3664(1994)

Saquinavir [Usan] Molecular Weight

670.841 g/mol

Saquinavir [Usan] Melting Point

349.84 ^oC

Saquinavir [Usan] H₂O Solubility

Insoluble

Saquinavir [Usan] State

Solid

Saquinavir [Usan] LogP

3.645

Saquinavir [Usan] Dosage Forms

Capsules

Saquinavir [Usan] Indication

For the treatment of HIV-1 with advanced immunodeficiency together with antiretroviral nucleoside analogues.

Saquinavir [Usan] Pharmacology

Saquinavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Saquinavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs.

Saquinavir [Usan] Absorption

Absolute bioavailability averages 4%

Saquinavir [Usan] side effects and Toxicity

Probably experience pain in the throat

Saquinavir [Usan] Patient Information

Saquinavir [Usan] Organisms Affected

Human immunodeficiency virus