Invirase
Invirase Brand names, Invirase Analogs
Invirase Brand Names Mixture
- No information avaliable
Invirase Chemical_Formula
C38H50N6O5
Invirase RX_link
http://www.rxlist.com/cgi/generic/saquin.htm
Invirase fda sheet
Invirase msds (material safety sheet)
Invirase Synthesis Reference
Parkes, Kevin E. B. et al., J. Org. Chem. 59(13) 3656-3664(1994)
Invirase Molecular Weight
670.841 g/mol
Invirase Melting Point
349.84 oC
Invirase H2O Solubility
Insoluble
Invirase State
Solid
Invirase LogP
3.645
Invirase Dosage Forms
Capsules
Invirase Indication
For the treatment of HIV-1 with advanced immunodeficiency together with antiretroviral nucleoside analogues.
Invirase Pharmacology
Saquinavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Saquinavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs.
Invirase Absorption
Absolute bioavailability averages 4%
Invirase side effects and Toxicity
Probably experience pain in the throat
Invirase Patient Information
Invirase Organisms Affected
Human immunodeficiency virus
