Saquinavir Mesylate
Saquinavir Mesylate Brand names, Saquinavir Mesylate Analogs
Saquinavir Mesylate Brand Names Mixture
- No information avaliable
Saquinavir Mesylate Chemical_Formula
C38H50N6O5
Saquinavir Mesylate RX_link
http://www.rxlist.com/cgi/generic/saquin.htm
Saquinavir Mesylate fda sheet
Saquinavir Mesylate msds (material safety sheet)
Saquinavir Mesylate Synthesis Reference
Parkes, Kevin E. B. et al., J. Org. Chem. 59(13) 3656-3664(1994)
Saquinavir Mesylate Molecular Weight
670.841 g/mol
Saquinavir Mesylate Melting Point
349.84 oC
Saquinavir Mesylate H2O Solubility
Insoluble
Saquinavir Mesylate State
Solid
Saquinavir Mesylate LogP
3.645
Saquinavir Mesylate Dosage Forms
Capsules
Saquinavir Mesylate Indication
For the treatment of HIV-1 with advanced immunodeficiency together with antiretroviral nucleoside analogues.
Saquinavir Mesylate Pharmacology
Saquinavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Saquinavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs.
Saquinavir Mesylate Absorption
Absolute bioavailability averages 4%
Saquinavir Mesylate side effects and Toxicity
Probably experience pain in the throat
Saquinavir Mesylate Patient Information
Saquinavir Mesylate Organisms Affected
Human immunodeficiency virus
