SQV
SQV Brand names, SQV Analogs
SQV Brand Names Mixture
- No information avaliable
SQV Chemical_Formula
C38H50N6O5
SQV RX_link
http://www.rxlist.com/cgi/generic/saquin.htm
SQV fda sheet
SQV msds (material safety sheet)
SQV Synthesis Reference
Parkes, Kevin E. B. et al., J. Org. Chem. 59(13) 3656-3664(1994)
SQV Molecular Weight
670.841 g/mol
SQV Melting Point
349.84 oC
SQV H2O Solubility
Insoluble
SQV State
Solid
SQV LogP
3.645
SQV Dosage Forms
Capsules
SQV Indication
For the treatment of HIV-1 with advanced immunodeficiency together with antiretroviral nucleoside analogues.
SQV Pharmacology
Saquinavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Saquinavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs.
SQV Absorption
Absolute bioavailability averages 4%
SQV side effects and Toxicity
Probably experience pain in the throat
SQV Patient Information
SQV Organisms Affected
Human immunodeficiency virus
