SQV en es it fr

SQV Brand names, SQV Analogs

SQV Brand Names Mixture

  • No information avaliable

SQV Chemical_Formula

C38H50N6O5

SQV RX_link

http://www.rxlist.com/cgi/generic/saquin.htm

SQV fda sheet

SQV FDA

SQV msds (material safety sheet)

SQV Synthesis Reference

Parkes, Kevin E. B. et al., J. Org. Chem. 59(13) 3656-3664(1994)

SQV Molecular Weight

670.841 g/mol

SQV Melting Point

349.84 oC

SQV H2O Solubility

Insoluble

SQV State

Solid

SQV LogP

3.645

SQV Dosage Forms

Capsules

SQV Indication

For the treatment of HIV-1 with advanced immunodeficiency together with antiretroviral nucleoside analogues.

SQV Pharmacology

Saquinavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Saquinavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs.

SQV Absorption

Absolute bioavailability averages 4%

SQV side effects and Toxicity

Probably experience pain in the throat

SQV Patient Information

SQV Organisms Affected

Human immunodeficiency virus