Regitine Mesylate
Brand names,
Regitine Mesylate
Analogs
Regitine Mesylate
Brand Names Mixture
Regitine Mesylate
Chemical_Formula
C17H19N3O
Regitine Mesylate
RX_link
http://www.rxlist.com/cgi/generic3/phentol.htm
Regitine Mesylate
fda sheet
Regitine Mesylate
msds (material safety sheet)
Regitine Mesylate
Synthesis Reference
No information avaliable
Regitine Mesylate
Molecular Weight
281.352 g/mol
Regitine Mesylate
Melting Point
174.5 oC
Regitine Mesylate
H2O Solubility
No information avaliable
Regitine Mesylate
State
Solid
Regitine Mesylate
LogP
2.551
Regitine Mesylate
Dosage Forms
Liquid
Regitine Mesylate
Indication
For the prevention or treatment of dermal necrosis and sloughing following intravenous administration or extravasation of norepinephrine. Also for the prevention or control of hypertensive episodes that may occur in a patient with pheochromocytoma as a result of stress or manipulation during preoperative preparation and surgical excision.
Regitine Mesylate
Pharmacology
Phentolamine is indicated for the control of episodes of hypertension and sweating that occur with a disease called pheochromocytoma. If tachycardia is excessive, it may be necessary to use a beta-blocking agent concomitantly. Phentolamine is a long-acting, adrenergic, alpha-receptor blocking agent which can produce and maintain "chemical sympathectomy" by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. Phentolamine works by blocking alpha receptors in certain parts of the body. Alpha receptors are present in the muscle that lines the walls of blood vessels. When the receptors are blocked by Phentolamine, the muscle relaxes and the blood vessels widen. This widening of the blood vessels results in a lowering of blood pressure.
Regitine Mesylate
Absorption
No information avaliable
Regitine Mesylate
side effects and Toxicity
No information avaliable
Regitine Mesylate
Patient Information
No information avaliable
Regitine Mesylate
Organisms Affected
Humans and other mammals