Phentolamine Mesilate
Phentolamine Mesilate Brand names, Phentolamine Mesilate Analogs
Phentolamine Mesilate Brand Names Mixture
- No information avaliable
Phentolamine Mesilate Chemical_Formula
C17H19N3O
Phentolamine Mesilate RX_link
http://www.rxlist.com/cgi/generic3/phentol.htm
Phentolamine Mesilate fda sheet
Phentolamine Mesilate msds (material safety sheet)
Phentolamine Mesilate Synthesis Reference
No information avaliable
Phentolamine Mesilate Molecular Weight
281.352 g/mol
Phentolamine Mesilate Melting Point
174.5 oC
Phentolamine Mesilate H2O Solubility
No information avaliable
Phentolamine Mesilate State
Solid
Phentolamine Mesilate LogP
2.551
Phentolamine Mesilate Dosage Forms
Liquid
Phentolamine Mesilate Indication
For the prevention or treatment of dermal necrosis and sloughing following intravenous administration or extravasation of norepinephrine. Also for the prevention or control of hypertensive episodes that may occur in a patient with pheochromocytoma as a result of stress or manipulation during preoperative preparation and surgical excision.
Phentolamine Mesilate Pharmacology
Phentolamine is indicated for the control of episodes of hypertension and sweating that occur with a disease called pheochromocytoma. If tachycardia is excessive, it may be necessary to use a beta-blocking agent concomitantly. Phentolamine is a long-acting, adrenergic, alpha-receptor blocking agent which can produce and maintain "chemical sympathectomy" by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. Phentolamine works by blocking alpha receptors in certain parts of the body. Alpha receptors are present in the muscle that lines the walls of blood vessels. When the receptors are blocked by Phentolamine, the muscle relaxes and the blood vessels widen. This widening of the blood vessels results in a lowering of blood pressure.
Phentolamine Mesilate Absorption
No information avaliable
Phentolamine Mesilate side effects and Toxicity
No information avaliable
Phentolamine Mesilate Patient Information
No information avaliable
Phentolamine Mesilate Organisms Affected
Humans and other mammals
