Phentolamine Mesylate
Phentolamine Mesylate Brand names, Phentolamine Mesylate Analogs
Phentolamine Mesylate Brand Names Mixture
- No information avaliable
Phentolamine Mesylate Chemical_Formula
C17H19N3O
Phentolamine Mesylate RX_link
http://www.rxlist.com/cgi/generic3/phentol.htm
Phentolamine Mesylate fda sheet
Phentolamine Mesylate msds (material safety sheet)
Phentolamine Mesylate Synthesis Reference
No information avaliable
Phentolamine Mesylate Molecular Weight
281.352 g/mol
Phentolamine Mesylate Melting Point
174.5 oC
Phentolamine Mesylate H2O Solubility
No information avaliable
Phentolamine Mesylate State
Solid
Phentolamine Mesylate LogP
2.551
Phentolamine Mesylate Dosage Forms
Liquid
Phentolamine Mesylate Indication
For the prevention or treatment of dermal necrosis and sloughing following intravenous administration or extravasation of norepinephrine. Also for the prevention or control of hypertensive episodes that may occur in a patient with pheochromocytoma as a result of stress or manipulation during preoperative preparation and surgical excision.
Phentolamine Mesylate Pharmacology
Phentolamine is indicated for the control of episodes of hypertension and sweating that occur with a disease called pheochromocytoma. If tachycardia is excessive, it may be necessary to use a beta-blocking agent concomitantly. Phentolamine is a long-acting, adrenergic, alpha-receptor blocking agent which can produce and maintain "chemical sympathectomy" by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. Phentolamine works by blocking alpha receptors in certain parts of the body. Alpha receptors are present in the muscle that lines the walls of blood vessels. When the receptors are blocked by Phentolamine, the muscle relaxes and the blood vessels widen. This widening of the blood vessels results in a lowering of blood pressure.
Phentolamine Mesylate Absorption
No information avaliable
Phentolamine Mesylate side effects and Toxicity
No information avaliable
Phentolamine Mesylate Patient Information
No information avaliable
Phentolamine Mesylate Organisms Affected
Humans and other mammals
