Phentalamine
Brand names,
Phentalamine
Analogs
Phentalamine
Brand Names Mixture
Phentalamine
Chemical_Formula
C17H19N3O
Phentalamine
RX_link
http://www.rxlist.com/cgi/generic3/phentol.htm
Phentalamine
fda sheet
Phentalamine
msds (material safety sheet)
Phentalamine
Synthesis Reference
No information avaliable
Phentalamine
Molecular Weight
281.352 g/mol
Phentalamine
Melting Point
174.5 oC
Phentalamine
H2O Solubility
No information avaliable
Phentalamine
State
Solid
Phentalamine
LogP
2.551
Phentalamine
Dosage Forms
Liquid
Phentalamine
Indication
For the prevention or treatment of dermal necrosis and sloughing following intravenous administration or extravasation of norepinephrine. Also for the prevention or control of hypertensive episodes that may occur in a patient with pheochromocytoma as a result of stress or manipulation during preoperative preparation and surgical excision.
Phentalamine
Pharmacology
Phentolamine is indicated for the control of episodes of hypertension and sweating that occur with a disease called pheochromocytoma. If tachycardia is excessive, it may be necessary to use a beta-blocking agent concomitantly. Phentolamine is a long-acting, adrenergic, alpha-receptor blocking agent which can produce and maintain "chemical sympathectomy" by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. Phentolamine works by blocking alpha receptors in certain parts of the body. Alpha receptors are present in the muscle that lines the walls of blood vessels. When the receptors are blocked by Phentolamine, the muscle relaxes and the blood vessels widen. This widening of the blood vessels results in a lowering of blood pressure.
Phentalamine
Absorption
No information avaliable
Phentalamine
side effects and Toxicity
No information avaliable
Phentalamine
Patient Information
No information avaliable
Phentalamine
Organisms Affected
Humans and other mammals