Phentolamine Methanesulphonate
Phentolamine Methanesulphonate Brand names, Phentolamine Methanesulphonate Analogs
Phentolamine Methanesulphonate Brand Names Mixture
- No information avaliable
Phentolamine Methanesulphonate Chemical_Formula
C17H19N3O
Phentolamine Methanesulphonate RX_link
http://www.rxlist.com/cgi/generic3/phentol.htm
Phentolamine Methanesulphonate fda sheet
Phentolamine Methanesulphonate msds (material safety sheet)
Phentolamine Methanesulphonate Synthesis Reference
No information avaliable
Phentolamine Methanesulphonate Molecular Weight
281.352 g/mol
Phentolamine Methanesulphonate Melting Point
174.5 oC
Phentolamine Methanesulphonate H2O Solubility
No information avaliable
Phentolamine Methanesulphonate State
Solid
Phentolamine Methanesulphonate LogP
2.551
Phentolamine Methanesulphonate Dosage Forms
Liquid
Phentolamine Methanesulphonate Indication
For the prevention or treatment of dermal necrosis and sloughing following intravenous administration or extravasation of norepinephrine. Also for the prevention or control of hypertensive episodes that may occur in a patient with pheochromocytoma as a result of stress or manipulation during preoperative preparation and surgical excision.
Phentolamine Methanesulphonate Pharmacology
Phentolamine is indicated for the control of episodes of hypertension and sweating that occur with a disease called pheochromocytoma. If tachycardia is excessive, it may be necessary to use a beta-blocking agent concomitantly. Phentolamine is a long-acting, adrenergic, alpha-receptor blocking agent which can produce and maintain "chemical sympathectomy" by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. Phentolamine works by blocking alpha receptors in certain parts of the body. Alpha receptors are present in the muscle that lines the walls of blood vessels. When the receptors are blocked by Phentolamine, the muscle relaxes and the blood vessels widen. This widening of the blood vessels results in a lowering of blood pressure.
Phentolamine Methanesulphonate Absorption
No information avaliable
Phentolamine Methanesulphonate side effects and Toxicity
No information avaliable
Phentolamine Methanesulphonate Patient Information
No information avaliable
Phentolamine Methanesulphonate Organisms Affected
Humans and other mammals
