Valid 08/2001 - 10/2001
Aldrich Chemical Co., Inc.
1001 West St. Paul
Milwaukee, WI 53233 USA
Tel: 414-273-3850
M A T E R I A L S A F E T Y D A T A S H E E T
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
CATALOG #: 284106
NAME: PINDOLOL, 97%
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
CAS #: 13523-86-9
MF: C14H20N2O2
EC NO: 236-867-9
SYNONYMS
CARVISKEN * 4-(2-HYDROXY-3-ISOPROPYLAMINOPROPOXY)-INDOLE * DL-4-(2-
HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)INDOLE * (+-)-4-(2-HYDROXY-3-
(ISOPROPYLAMINO)PROPOXY)INDOLE * 1-(4-INDOLYLOXY)-3-(ISOPROPYLAMINO)-
2-PROPANOL * 1-(1H-INDOL-4-YLOXY)-3-((1-METHYLETHYL)AMINO)-2-PROPANOL
* 4-(3-(ISOPROPYLAMINO)-2-HYDROXYPROPOXY)INDOLE * LB 46 * DL-LB 46 *
(+-)-LB 46 * 1-((1-METHYLETHYL)AMINO)-3-(4-INDOLYLOXY)-2-PROPANOL *
DL-PINDOLOL * DL-PINDOLOL * DL-PINDOLOL * (RS)-PINDOLOL * (+-)-
PINDOLOL * PRINODOLOL * 2-PROPANOL, 1-(4-INDOLYLOXY)-3-
(ISOPROPYLAMINO)- * VISKEN *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
LABEL PRECAUTIONARY STATEMENTS
TOXIC (USA)
HARMFUL (EU)
HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
TARGET ORGAN(S):
HEART
LUNGS
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
WEAR SUITABLE PROTECTIVE CLOTHING.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
IN CASE OF SKIN CONTACT, FLUSH WITH COPIOUS AMOUNTS OF WATER
FOR AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND
SHOES. CALL A PHYSICIAN.
IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF WATER
FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING
THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
EXTINGUISHING MEDIA
WATER SPRAY.
CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
UNUSUAL FIRE AND EXPLOSIONS HAZARDS
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
WEAR RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS AND HEAVY
RUBBER GLOVES.
SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
AVOID RAISING DUST.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
SAFETY SHOWER AND EYE BATH.
MECHANICAL EXHAUST REQUIRED.
DO NOT BREATHE DUST.
AVOID CONTACT WITH EYES, SKIN AND CLOTHING.
AVOID PROLONGED OR REPEATED EXPOSURE.
NIOSH/MSHA-APPROVED RESPIRATOR.
COMPATIBLE CHEMICAL-RESISTANT GLOVES.
CHEMICAL SAFETY GOGGLES.
STORE IN A COOL DRY PLACE.
KEEP TIGHTLY CLOSED.
WASH THOROUGHLY AFTER HANDLING.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
APPEARANCE AND ODOR
WHITE POWDER
PHYSICAL PROPERTIES
MELTING POINT: 167 C TO 171 C
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
STABILITY
STABLE.
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
CARBON MONOXIDE, CARBON DIOXIDE
NITROGEN OXIDES
HAZARDOUS POLYMERIZATION
WILL NOT OCCUR.
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
ACUTE EFFECTS
CAUSES SKIN IRRITATION.
CAUSES EYE IRRITATION.
MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT.
HARMFUL IF SWALLOWED, INHALED, OR ABSORBED THROUGH SKIN.
ADVERSE REACTIONS: HYPERHIDROSIS, BRADYCARDIA, CLAUDICATION, HEART
BLOCK, HYPOTENSION, SYNCOPE, TACHYCARDIA, DIARRHEA, VOMITING,
WHEEZING, IMPOTENCE, POLLAKIURIA, AGRANULOCYTOSIS, THROMBOCYTOPENIC
AND NON-THROMBOCYTOPENIC PURPURA, LARYNGOSPASM, ISCHEMIC COLITIS,
MESENTERIC ARTERIAL THROMBOSIS, REVERSIBLE ALOPECIA.
RTECS #: UB6660000
2-PROPANOL, 1-(1H-INDOL-4-YLOXY)-3-((1-METHYLETHYL)AMINO)-
TOXICITY DATA
ORL-RAT LD50:263 MG/KG NIGZAY 84,438,1970
IPR-RAT LD50:110 MG/KG IYKEDH 4,90,1973
SCU-RAT LD50:251 MG/KG NIGZAY 84,438,1970
IVN-RAT LD50:51 MG/KG NIGZAY 84,438,1970
ORL-MUS LD50:235 MG/KG JTSCDR 6,301,1981
IPR-MUS LD50:80 MG/KG YACHDS 9,3573,1981
SCU-MUS LD50:336 MG/KG NIGZAY 84,438,1970
IVN-MUS LD50:22600 UG/KG ARZNAD 28,794,1978
ORL-RBT LD50:650 MG/KG NIGZAY 84,438,1970
IVN-RBT LD50:10 MG/KG NIGZAY 84,438,1970
TARGET ORGAN DATA
SENSE ORGANS AND SPECIAL SENSES (MYDRIASIS)
BEHAVIORAL (SOMNOLENCE)
BEHAVIORAL (TREMOR)
BEHAVIORAL (CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD)
BEHAVIORAL (ATAXIA)
LUNGS, THORAX OR RESPIRATION (DYSPNAE)
LUNGS, THORAX OR RESPIRATION (RESPIRATORY DEPRESSION)
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
CONTACT ALDRICH CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
EUROPEAN INFORMATION
HARMFUL
R 20/21/22
HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
R 36/37/38
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
S 36
WEAR SUITABLE PROTECTIVE CLOTHING.
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 2001 SIGMA-ALDRICH CO.
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY
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