Protonix I.V.
Brand names,
Protonix I.V.
Analogs
Protonix I.V.
Brand Names Mixture
Protonix I.V.
Chemical_Formula
C16H15F2N3O4S
Protonix I.V.
RX_link
http://www.rxlist.com/cgi/generic3/protonix.htm
Protonix I.V.
fda sheet
Protonix I.V.
msds (material safety sheet)
Protonix I.V.
Synthesis Reference
No information avaliable
Protonix I.V.
Molecular Weight
383.371 g/mol
Protonix I.V.
Melting Point
Because of gradual degradation of pantoprazole sodium during heating, the melting point cannot be determined.
Protonix I.V.
H2O Solubility
Freely soluble in water.
Protonix I.V.
State
Solid
Protonix I.V.
LogP
1.268
Protonix I.V.
Dosage Forms
Tablet (enteric-coated)
Protonix I.V.
Indication
Short-term (up to 16 weeks) treatment of erosive esophagitis.
Protonix I.V.
Pharmacology
Pantoprazole is a substituted benzimidazole indicated for the short-term treatment (up to 16 weeks) in the healing and symptomatic relief of erosive esophagitis. Pantoprazole is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production.
Protonix I.V.
Absorption
Pantoprazole is well absorbed; it undergoes little first-pass metabolism resulting in an absolute bioavailability of approximately 77%.
Protonix I.V.
side effects and Toxicity
No information avaliable
Protonix I.V.
Patient Information
Patients should be cautioned that PROTONIX Delayed-Release Tablets should not be split, crushed or chewed. The
tablets should be swallowed whole, with or without food in the stomach. Concomitant administration of antacids does
not affect the absorption of pantoprazole.
Protonix I.V.
Organisms Affected
Humans and other mammals