Protamine and Atropine en es it fr

Protamine and Atropine Brand names, Protamine and Atropine Analogs

Protamine and Atropine Brand Names Mixture

  • No information avaliable

Protamine and Atropine Chemical_Formula


Protamine and Atropine RX_link

Protamine and Atropine fda sheet

Protamine_and_Atropine FDA

Protamine and Atropine msds (material safety sheet)

Protamine_and_Atropine MSDS

Protamine and Atropine Synthesis Reference

No information avaliable

Protamine and Atropine Molecular Weight

289.369 g/mol

Protamine and Atropine Melting Point

118.5 oC

Protamine and Atropine H2O Solubility

Highly soluble (2200 mg/L)

Protamine and Atropine State


Protamine and Atropine LogP


Protamine and Atropine Dosage Forms

Drops; Liquid; Ointment; Solution

Protamine and Atropine Indication

For the treatment of poisoning by susceptible organophosphorous nerve agents having cholinesterase activity as well as organophosphorous or carbamate insecticides.

Protamine and Atropine Pharmacology

Atropine, a naturally occurring belladonna alkaloid, is a racemic mixture of equal parts of d- and l-hyoscyamine, whose activity is due almost entirely to the levo isomer of the drug. Atropine is commonly classified as an anticholinergic or antiparasympathetic (parasympatholytic) drug. More precisely, however, it is termed an antimuscarinic agent since it antagonizes the muscarine-like actions of acetylcholine and other choline esters. Adequate doses of atropine abolish various types of reflex vagal cardiac slowing or asystole. The drug also prevents or abolishes bradycardia or asystole produced by injection of choline esters, anticholinesterase agents or other parasympathomimetic drugs, and cardiac arrest produced by stimulation of the vagus. Atropine may also lessen the degree of partial heart block when vagal activity is an etiologic factor. Atropine in clinical doses counteracts the peripheral dilatation and abrupt decrease in blood pressure produced by choline esters. However, when given by itself, atropine does not exert a striking or uniform effect on blood vessels or blood pressure.

Protamine and Atropine Absorption

Atropine is rapidly and well absorbed after intramuscular administration. Atropine disappears rapidly from the blood and is distributed throughout the various body tissues and fluids.

Protamine and Atropine side effects and Toxicity

Oral, mouse: LD50 = 75 mg/kg. Symptoms of overdose includes widespread paralysis of parasympathetically innervated organs. Dry mucous membranes, widely dilated and nonresponsive pupils, tachycardia, fever and cutaneous flush are especially prominent, as are mental and neurological symptoms. In instances of severe intoxication, respiratory depression, coma, circulatory collapse and death may occur.

Protamine and Atropine Patient Information

Protamine and Atropine Organisms Affected

Humans and other mammals