Protamine and Atropine
Protamine and Atropine Brand names, Protamine and Atropine Analogs
- Atnaa
- Atropair
- Atropen
- Atropin
- Atropin [German]
- Atropin-flexiolen
- Atropina
- Atropina [Italian]
- Atropine Care
- Atropine Sulfate
- Atropine Sulfate Ansyr Plastic Syringe
- Atropine Sulfate S.O.P.
- Atropinol
- Atropisol
- Atrosulf
- DL-Hyoscyamine
- DL-Tropyl tropate
- Equipin
- Eyesules
- Homapin-10
- Homapin-5
- Hyoscyamine
- I-Tropine
- Isopto Atropine
- Isopto-atropine
- Minims Atropine
- Ocu-Tropine
- Protamine + Atropine
- Protamine and Atropine
- Tropic acid, ester with tropine
- Tropine tropate
- Troyl tropate
Protamine and Atropine Brand Names Mixture
- No information avaliable
Protamine and Atropine Chemical_Formula
C17H23NO3
Protamine and Atropine RX_link
http://www.rxlist.com/cgi/generic3/atropen.htm
Protamine and Atropine fda sheet
Protamine and Atropine msds (material safety sheet)
Protamine and Atropine Synthesis Reference
No information avaliable
Protamine and Atropine Molecular Weight
289.369 g/mol
Protamine and Atropine Melting Point
118.5 oC
Protamine and Atropine H2O Solubility
Highly soluble (2200 mg/L)
Protamine and Atropine State
Solid
Protamine and Atropine LogP
2.904
Protamine and Atropine Dosage Forms
Drops; Liquid; Ointment; Solution
Protamine and Atropine Indication
For the treatment of poisoning by susceptible organophosphorous nerve agents having cholinesterase activity as well as organophosphorous or carbamate insecticides.
Protamine and Atropine Pharmacology
Atropine, a naturally occurring belladonna alkaloid, is a racemic mixture of equal parts of d- and l-hyoscyamine, whose activity is due almost entirely to the levo isomer of the drug. Atropine is commonly classified as an anticholinergic or antiparasympathetic (parasympatholytic) drug. More precisely, however, it is termed an antimuscarinic agent since it antagonizes the muscarine-like actions of acetylcholine and other choline esters. Adequate doses of atropine abolish various types of reflex vagal cardiac slowing or asystole. The drug also prevents or abolishes bradycardia or asystole produced by injection of choline esters, anticholinesterase agents or other parasympathomimetic drugs, and cardiac arrest produced by stimulation of the vagus. Atropine may also lessen the degree of partial heart block when vagal activity is an etiologic factor. Atropine in clinical doses counteracts the peripheral dilatation and abrupt decrease in blood pressure produced by choline esters. However, when given by itself, atropine does not exert a striking or uniform effect on blood vessels or blood pressure.
Protamine and Atropine Absorption
Atropine is rapidly and well absorbed after intramuscular administration. Atropine disappears rapidly from the blood and is distributed throughout the various body tissues and fluids.
Protamine and Atropine side effects and Toxicity
Oral, mouse: LD50 = 75 mg/kg. Symptoms of overdose includes widespread paralysis of parasympathetically innervated organs. Dry mucous membranes, widely dilated and nonresponsive pupils, tachycardia, fever and cutaneous flush are especially prominent, as are mental and neurological symptoms. In instances of severe intoxication, respiratory depression, coma, circulatory collapse and death may occur.
Protamine and Atropine Patient Information
Protamine and Atropine Organisms Affected
Humans and other mammals
