DL-Tropyl tropate

DL-Tropyl tropate Brand names, DL-Tropyl tropate Analogs

DL-Tropyl tropate Brand Names Mixture

No information avaliable

DL-Tropyl tropate Chemical_Formula

C₁₇H₂₃NO₃

DL-Tropyl tropate RX_link

http://www.rxlist.com/cgi/generic3/atropen.htm

DL-Tropyl tropate fda sheet

DL-Tropyl_tropate FDA

DL-Tropyl tropate msds (material safety sheet)

DL-Tropyl_tropate MSDS

DL-Tropyl tropate Synthesis Reference

No information avaliable

DL-Tropyl tropate Molecular Weight

289.369 g/mol

DL-Tropyl tropate Melting Point

118.5 ^oC

DL-Tropyl tropate H₂O Solubility

Highly soluble (2200 mg/L)

DL-Tropyl tropate State

Solid

DL-Tropyl tropate LogP

2.904

DL-Tropyl tropate Dosage Forms

Drops; Liquid; Ointment; Solution

DL-Tropyl tropate Indication

For the treatment of poisoning by susceptible organophosphorous nerve agents having cholinesterase activity as well as organophosphorous or carbamate insecticides.

DL-Tropyl tropate Pharmacology

Atropine, a naturally occurring belladonna alkaloid, is a racemic mixture of equal parts of d- and l-hyoscyamine, whose activity is due almost entirely to the levo isomer of the drug. Atropine is commonly classified as an anticholinergic or antiparasympathetic (parasympatholytic) drug. More precisely, however, it is termed an antimuscarinic agent since it antagonizes the muscarine-like actions of acetylcholine and other choline esters. Adequate doses of atropine abolish various types of reflex vagal cardiac slowing or asystole. The drug also prevents or abolishes bradycardia or asystole produced by injection of choline esters, anticholinesterase agents or other parasympathomimetic drugs, and cardiac arrest produced by stimulation of the vagus. Atropine may also lessen the degree of partial heart block when vagal activity is an etiologic factor. Atropine in clinical doses counteracts the peripheral dilatation and abrupt decrease in blood pressure produced by choline esters. However, when given by itself, atropine does not exert a striking or uniform effect on blood vessels or blood pressure.

DL-Tropyl tropate Absorption

Atropine is rapidly and well absorbed after intramuscular administration. Atropine disappears rapidly from the blood and is distributed throughout the various body tissues and fluids.

DL-Tropyl tropate side effects and Toxicity

Oral, mouse: LD₅₀ = 75 mg/kg. Symptoms of overdose includes widespread paralysis of parasympathetically innervated organs. Dry mucous membranes, widely dilated and nonresponsive pupils, tachycardia, fever and cutaneous flush are especially prominent, as are mental and neurological symptoms. In instances of severe intoxication, respiratory depression, coma, circulatory collapse and death may occur.

DL-Tropyl tropate Patient Information

DL-Tropyl tropate Organisms Affected

Humans and other mammals