Atropina [Italian]

Atropina [Italian] Brand names, Atropina [Italian] Analogs

Atropina [Italian] Brand Names Mixture

No information avaliable

Atropina [Italian] Chemical_Formula

C₁₇H₂₃NO₃

Atropina [Italian] RX_link

http://www.rxlist.com/cgi/generic3/atropen.htm

Atropina [Italian] fda sheet

Atropina_[Italian] FDA

Atropina [Italian] msds (material safety sheet)

Atropina_[Italian] MSDS

Atropina [Italian] Synthesis Reference

No information avaliable

Atropina [Italian] Molecular Weight

289.369 g/mol

Atropina [Italian] Melting Point

118.5 ^oC

Atropina [Italian] H₂O Solubility

Highly soluble (2200 mg/L)

Atropina [Italian] State

Solid

Atropina [Italian] LogP

2.904

Atropina [Italian] Dosage Forms

Drops; Liquid; Ointment; Solution

Atropina [Italian] Indication

For the treatment of poisoning by susceptible organophosphorous nerve agents having cholinesterase activity as well as organophosphorous or carbamate insecticides.

Atropina [Italian] Pharmacology

Atropine, a naturally occurring belladonna alkaloid, is a racemic mixture of equal parts of d- and l-hyoscyamine, whose activity is due almost entirely to the levo isomer of the drug. Atropine is commonly classified as an anticholinergic or antiparasympathetic (parasympatholytic) drug. More precisely, however, it is termed an antimuscarinic agent since it antagonizes the muscarine-like actions of acetylcholine and other choline esters. Adequate doses of atropine abolish various types of reflex vagal cardiac slowing or asystole. The drug also prevents or abolishes bradycardia or asystole produced by injection of choline esters, anticholinesterase agents or other parasympathomimetic drugs, and cardiac arrest produced by stimulation of the vagus. Atropine may also lessen the degree of partial heart block when vagal activity is an etiologic factor. Atropine in clinical doses counteracts the peripheral dilatation and abrupt decrease in blood pressure produced by choline esters. However, when given by itself, atropine does not exert a striking or uniform effect on blood vessels or blood pressure.

Atropina [Italian] Absorption

Atropine is rapidly and well absorbed after intramuscular administration. Atropine disappears rapidly from the blood and is distributed throughout the various body tissues and fluids.

Atropina [Italian] side effects and Toxicity

Oral, mouse: LD₅₀ = 75 mg/kg. Symptoms of overdose includes widespread paralysis of parasympathetically innervated organs. Dry mucous membranes, widely dilated and nonresponsive pupils, tachycardia, fever and cutaneous flush are especially prominent, as are mental and neurological symptoms. In instances of severe intoxication, respiratory depression, coma, circulatory collapse and death may occur.

Atropina [Italian] Patient Information

Atropina [Italian] Organisms Affected

Humans and other mammals