PharmacyCodes



I-Tropine en es it fr

I-Tropine Brand names, I-Tropine Analogs

I-Tropine Brand Names Mixture

  • No information avaliable

I-Tropine Chemical_Formula

C17H23NO3

I-Tropine RX_link

http://www.rxlist.com/cgi/generic3/atropen.htm

I-Tropine fda sheet

I-Tropine FDA

I-Tropine msds (material safety sheet)

I-Tropine MSDS

I-Tropine Synthesis Reference

No information avaliable

I-Tropine Molecular Weight

289.369 g/mol

I-Tropine Melting Point

118.5 oC

I-Tropine H2O Solubility

Highly soluble (2200 mg/L)

I-Tropine State

Solid

I-Tropine LogP

2.904

I-Tropine Dosage Forms

Drops; Liquid; Ointment; Solution

I-Tropine Indication

For the treatment of poisoning by susceptible organophosphorous nerve agents having cholinesterase activity as well as organophosphorous or carbamate insecticides.

I-Tropine Pharmacology

Atropine, a naturally occurring belladonna alkaloid, is a racemic mixture of equal parts of d- and l-hyoscyamine, whose activity is due almost entirely to the levo isomer of the drug. Atropine is commonly classified as an anticholinergic or antiparasympathetic (parasympatholytic) drug. More precisely, however, it is termed an antimuscarinic agent since it antagonizes the muscarine-like actions of acetylcholine and other choline esters. Adequate doses of atropine abolish various types of reflex vagal cardiac slowing or asystole. The drug also prevents or abolishes bradycardia or asystole produced by injection of choline esters, anticholinesterase agents or other parasympathomimetic drugs, and cardiac arrest produced by stimulation of the vagus. Atropine may also lessen the degree of partial heart block when vagal activity is an etiologic factor. Atropine in clinical doses counteracts the peripheral dilatation and abrupt decrease in blood pressure produced by choline esters. However, when given by itself, atropine does not exert a striking or uniform effect on blood vessels or blood pressure.

I-Tropine Absorption

Atropine is rapidly and well absorbed after intramuscular administration. Atropine disappears rapidly from the blood and is distributed throughout the various body tissues and fluids.

I-Tropine side effects and Toxicity

Oral, mouse: LD50 = 75 mg/kg. Symptoms of overdose includes widespread paralysis of parasympathetically innervated organs. Dry mucous membranes, widely dilated and nonresponsive pupils, tachycardia, fever and cutaneous flush are especially prominent, as are mental and neurological symptoms. In instances of severe intoxication, respiratory depression, coma, circulatory collapse and death may occur.

I-Tropine Patient Information

I-Tropine Organisms Affected

Humans and other mammals