Pentam

Pentam Brand names, Pentam Analogs

Pentam Brand Names Mixture

No information avaliable

Pentam Chemical_Formula

C₁₉H₂₄N₄O₂

Pentam RX_link

http://www.rxlist.com/cgi/generic3/pentam.htm

Pentam fda sheet

Pentam msds (material safety sheet)

Pentam MSDS

Pentam Synthesis Reference

No information avaliable

Pentam Molecular Weight

340.42 g/mol

Pentam Melting Point

186.0 ^oC (decomposes)

Pentam H₂O Solubility

Complete

Pentam State

Solid

Pentam LogP

3.28

Pentam Dosage Forms

Powder for solution

Pentam Indication

For the treatment of pneumonia due to Pneumocystis carinii.

Pentam Pharmacology

Pentamidine is an antiprotozoal agent. It is an aromatic diamidine, and is known to have activity against Pneumocystis carinii. The exact nature of its antiprotozoal action is unknown. in vitro studies with mammalian tissues and the protozoan Crithidia oncopelti indicate that the drug interferes with nuclear metabolism producing inhibition of the synthesis of DNA, RNA, phospholipids and proteins. Little is known about the drug's pharmacokinetics. The medication is also useful in Leishmaniasis and in prophylaxis against sleeping sickness caused by Trypanosoma brucei gambiense. Hydration before treatment lessens the incidence and severity of side effects, which include liver or kidney dysfunction, hypertension, hypotension, hypoglycemia, hypocalemia, leukopenia, thrombcytopenia, anemia, and allergic reaction. It is generally well-tolerated.

Pentam Absorption

Absorbed poorly through the gastrointestinal tract and is usually administered parenterally.

Pentam side effects and Toxicity

Symptoms of overdose include pain, nausea, anorexia, hypotension, fever, rash, bad taste in mouth, confusion/hallucinations, dizziness, and diarrhea.

Pentam Patient Information