PNT

PNT Brand names, PNT Analogs

PNT Brand Names Mixture

No information avaliable

PNT Chemical_Formula

C₁₉H₂₄N₄O₂

PNT RX_link

http://www.rxlist.com/cgi/generic3/pentam.htm

PNT fda sheet

PNT msds (material safety sheet)

PNT MSDS

PNT Synthesis Reference

No information avaliable

PNT Molecular Weight

340.42 g/mol

PNT Melting Point

186.0 ^oC (decomposes)

PNT H₂O Solubility

Complete

PNT State

Solid

PNT LogP

3.28

PNT Dosage Forms

Powder for solution

PNT Indication

For the treatment of pneumonia due to Pneumocystis carinii.

PNT Pharmacology

Pentamidine is an antiprotozoal agent. It is an aromatic diamidine, and is known to have activity against Pneumocystis carinii. The exact nature of its antiprotozoal action is unknown. in vitro studies with mammalian tissues and the protozoan Crithidia oncopelti indicate that the drug interferes with nuclear metabolism producing inhibition of the synthesis of DNA, RNA, phospholipids and proteins. Little is known about the drug's pharmacokinetics. The medication is also useful in Leishmaniasis and in prophylaxis against sleeping sickness caused by Trypanosoma brucei gambiense. Hydration before treatment lessens the incidence and severity of side effects, which include liver or kidney dysfunction, hypertension, hypotension, hypoglycemia, hypocalemia, leukopenia, thrombcytopenia, anemia, and allergic reaction. It is generally well-tolerated.

PNT Absorption

Absorbed poorly through the gastrointestinal tract and is usually administered parenterally.

PNT side effects and Toxicity

Symptoms of overdose include pain, nausea, anorexia, hypotension, fever, rash, bad taste in mouth, confusion/hallucinations, dizziness, and diarrhea.

PNT Patient Information