NebuPent

NebuPent Brand names, NebuPent Analogs

NebuPent Brand Names Mixture

No information avaliable

NebuPent Chemical_Formula

C₁₉H₂₄N₄O₂

NebuPent RX_link

http://www.rxlist.com/cgi/generic3/pentam.htm

NebuPent fda sheet

NebuPent msds (material safety sheet)

NebuPent MSDS

NebuPent Synthesis Reference

No information avaliable

NebuPent Molecular Weight

340.42 g/mol

NebuPent Melting Point

186.0 ^oC (decomposes)

NebuPent H₂O Solubility

Complete

NebuPent State

Solid

NebuPent LogP

3.28

NebuPent Dosage Forms

Powder for solution

NebuPent Indication

For the treatment of pneumonia due to Pneumocystis carinii.

NebuPent Pharmacology

Pentamidine is an antiprotozoal agent. It is an aromatic diamidine, and is known to have activity against Pneumocystis carinii. The exact nature of its antiprotozoal action is unknown. in vitro studies with mammalian tissues and the protozoan Crithidia oncopelti indicate that the drug interferes with nuclear metabolism producing inhibition of the synthesis of DNA, RNA, phospholipids and proteins. Little is known about the drug's pharmacokinetics. The medication is also useful in Leishmaniasis and in prophylaxis against sleeping sickness caused by Trypanosoma brucei gambiense. Hydration before treatment lessens the incidence and severity of side effects, which include liver or kidney dysfunction, hypertension, hypotension, hypoglycemia, hypocalemia, leukopenia, thrombcytopenia, anemia, and allergic reaction. It is generally well-tolerated.

NebuPent Absorption

Absorbed poorly through the gastrointestinal tract and is usually administered parenterally.

NebuPent side effects and Toxicity

Symptoms of overdose include pain, nausea, anorexia, hypotension, fever, rash, bad taste in mouth, confusion/hallucinations, dizziness, and diarrhea.

NebuPent Patient Information