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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C19H18ClN3O5S
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RX_link
No information avaliable
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
435.882 g/mol
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Melting Point
No information avaliable
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H2O Solubility
13.9 mg/L
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State
Solid
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LogP
2.274
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Dosage Forms
Capsules (250 mg, 500 mg); Powder (125 mg/5 mL when reconstituted)
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Indication
Used to treat infections caused by penicillinase-producing staphylococci, including pneumococci, group A beta-hemolytic streptococci, and penicillin G-sensitive and penicillin G-resistant staphylococci.
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Pharmacology
Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin is for use against staphylococci that produce beta-lactamase.
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Absorption
Well absorbed from the gastrointestinal tract.
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side effects and Toxicity
Oral LD50 in rat and mouse is 5000 mg/kg. Intravenous LD50 in rat is 1660 mg/kg. Symptoms of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, and swelling of face, lips, tongue, or throat.
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Patient Information
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Organisms Affected
Enteric bacteria and other eubacteria