Oxiconazol [INN-Spanish]
Brand names,
Oxiconazol [INN-Spanish]
Analogs
Oxiconazol [INN-Spanish]
Brand Names Mixture
Oxiconazol [INN-Spanish]
Chemical_Formula
C18H13Cl4N3O
Oxiconazol [INN-Spanish]
RX_link
http://www.rxlist.com/cgi/generic3/oxico.htm
Oxiconazol [INN-Spanish]
fda sheet
Oxiconazol [INN-Spanish]
msds (material safety sheet)
Oxiconazol [INN-Spanish]
Synthesis Reference
No information avaliable
Oxiconazol [INN-Spanish]
Molecular Weight
429.126 g/mol
Oxiconazol [INN-Spanish]
Melting Point
No information avaliable
Oxiconazol [INN-Spanish]
H2O Solubility
No information avaliable
Oxiconazol [INN-Spanish]
State
Solid
Oxiconazol [INN-Spanish]
LogP
5.983
Oxiconazol [INN-Spanish]
Dosage Forms
Cream; Lotion
Oxiconazol [INN-Spanish]
Indication
For treatment of dermal fungal infection.
Oxiconazol [INN-Spanish]
Pharmacology
Oxiconazole nitrate is a broad-spectrum imidazole derivative whose antifungal activity is derived primarily from the inhibition of ergosterol biosynthesis, which is critical for cellular membrane integrity. It has fungicidal or fungistatic activity in vitro against a number of pathogenic fungi including the following dermatophytes, and yeasts: T. rubrum, T. mentagrophytes, T. tonsurans, T. violaceum, E. floccosum, M. canis, M. audouini, M. gypseum, C. albicans, and M. furfur.
Oxiconazol [INN-Spanish]
Absorption
Systemic absorption of oxiconazole nitrate is low.
Oxiconazol [INN-Spanish]
side effects and Toxicity
Side effects incliude pruritus, burning, irritation, erythema, stinging and allergic contact dermatitis and folliculitis, fissuring, maceration rash and nodules.
Oxiconazol [INN-Spanish]
Patient Information
Oxiconazol [INN-Spanish]
Organisms Affected
Fungi