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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C17H19N3O3S
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RX_link
http://www.rxlist.com/cgi/generic3/esomeprazole.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
345.417 g/mol
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Melting Point
155 oC
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H2O Solubility
Very slightly soluble in water
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State
Solid
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LogP
1.078
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Dosage Forms
Tablet (delayed-release); Delayed-release capsules; IV injection solution; IV iufusion solution
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Indication
For the treatment of acid-reflux disorders (GERD) and peptic ulcer disease
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Pharmacology
Esomeprazole is a compound that inhibits gastric acid secretion and is indicated in the treatment of gastroesophageal reflux disease (GERD), the healing of erosive esophagitis, and H. pylori eradication to reduce the risk of duodenal ulcer recurrence. Esomeprazole belongs to a new class of antisecretory compounds, the substituted benzimidazoles, that do not exhibit anticholinergic or H2 histamine antagonistic properties, but that suppress gastric acid secretion by specific inhibition of the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell. Because this enzyme system is regarded as the acid (proton) pump within the gastric mucosa, Esomeprazole has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production. This effect is dose-related and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus.
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Absorption
90%
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side effects and Toxicity
Blurred vision, confusion, drowsiness, dry mouthflushingheadache, nausea, rapid heartbeat, sweating
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals