Nexium

• Antihistamines
• Anti-Ulcer Agents
• Enzyme Inhibitors
• Proton-pump Inhibitors
• ATC:A02BC05

• Esomeprazole Magnesium
• Esomeprazole Sodium
• Esomeprazole and Salts
• Esomperazole
• Nexiam
• Nexium
• Nexium Iv
• Omeprazole
• Prilosec
• Zegerid

• No information avaliable

C₁₇H₁₉N₃O₃S

http://www.rxlist.com/cgi/generic3/esomeprazole.htm

Nexium FDA

No information avaliable

345.417 g/mol

155 ^oC

Very slightly soluble in water

Solid

1.078

Tablet (delayed-release); Delayed-release capsules; IV injection solution; IV iufusion solution

For the treatment of acid-reflux disorders (GERD) and peptic ulcer disease

Esomeprazole is a compound that inhibits gastric acid secretion and is indicated in the treatment of gastroesophageal reflux disease (GERD), the healing of erosive esophagitis, and H. pylori eradication to reduce the risk of duodenal ulcer recurrence. Esomeprazole belongs to a new class of antisecretory compounds, the substituted benzimidazoles, that do not exhibit anticholinergic or H2 histamine antagonistic properties, but that suppress gastric acid secretion by specific inhibition of the H⁺/K⁺ ATPase enzyme system at the secretory surface of the gastric parietal cell. Because this enzyme system is regarded as the acid (proton) pump within the gastric mucosa, Esomeprazole has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production. This effect is dose-related and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus.

90%

Blurred vision, confusion, drowsiness, dry mouthflushingheadache, nausea, rapid heartbeat, sweating

No information avaliable

Humans and other mammals