PharmacyCodes



Nabuser en es it fr

Nabuser Brand names, Nabuser Analogs

Nabuser Brand Names Mixture

  • No information avaliable

Nabuser Chemical_Formula

C12H12N2O3

Nabuser RX_link

http://www.rxlist.com/cgi/generic2/nalidixicacid.htm

Nabuser fda sheet

Nabuser FDA

Nabuser msds (material safety sheet)

Nabuser MSDS

Nabuser Synthesis Reference

No information avaliable

Nabuser Molecular Weight

232.235 g/mol

Nabuser Melting Point

229.5 oC

Nabuser H2O Solubility

100 mg/L

Nabuser State

Solid

Nabuser LogP

0.949

Nabuser Dosage Forms

Suspension (250 mg/5 mL tsp); Tablets (1000 mg, 500 mg, 250 mg)

Nabuser Indication

For the treatment of urinary tract infections caused by susceptible gram-negative microorganisms, including the majority of E. Coli, Enterobacter species, Klebsiella species, and Proteus species.

Nabuser Pharmacology

Nalidixic acid is a quinolone antibacterial agent for oral administration. Nalidixic acid has marked antibacterial activity against gram-negative bacteria including Enterobacter species, Escherichia coli, Morganella Morganii; Proteus Mirabilis, Proteus vulgaris, and Providencia rettgeri. Pseudomonas species are generally resistant to the drug. Nalidixic acid is bactericidal and is effective over the entire urinary pH range. Conventional chromosomal resistance to nalidixic acid taken in full dosage has been reported to emerge in approximately 2 to 14 percent of patients during treatment; however, bacterial resistance to nalidixic acid has not been shown to be transferable via R factor.

Nabuser Absorption

Following oral administration, nalidixic acid is rapidly absorbed from the gastrointestinal tract. Bioavailability is approximately 96%. Absorption may be delayed if taken with antacids.

Nabuser side effects and Toxicity

ORAL (LD50): Acute: 1160 mg/kg [Rat]. 572 mg/kg [Mouse]. Toxic psychosis, convulsions, increased intracranial pressure, or metabolic acidosis may occur in patients taking more than the recommended dosage. Vomiting, nausea, and lethargy may also occur following overdosage.

Nabuser Patient Information

Nabuser Organisms Affected

Enteric bacteria and other eubacteria