Mebutan

Mebutan Brand names, Mebutan Analogs

Mebutan Brand Names Mixture

No information avaliable

Mebutan Chemical_Formula

C₁₂H₁₂N₂O₃

Mebutan RX_link

http://www.rxlist.com/cgi/generic2/nalidixicacid.htm

Mebutan fda sheet

Mebutan FDA

Mebutan msds (material safety sheet)

Mebutan MSDS

Mebutan Synthesis Reference

No information avaliable

Mebutan Molecular Weight

232.235 g/mol

Mebutan Melting Point

229.5 ^oC

Mebutan H₂O Solubility

100 mg/L

Mebutan State

Solid

Mebutan LogP

0.949

Mebutan Dosage Forms

Suspension (250 mg/5 mL tsp); Tablets (1000 mg, 500 mg, 250 mg)

Mebutan Indication

For the treatment of urinary tract infections caused by susceptible gram-negative microorganisms, including the majority of E. Coli, Enterobacter species, Klebsiella species, and Proteus species.

Mebutan Pharmacology

Nalidixic acid is a quinolone antibacterial agent for oral administration. Nalidixic acid has marked antibacterial activity against gram-negative bacteria including Enterobacter species, Escherichia coli, Morganella Morganii; Proteus Mirabilis, Proteus vulgaris, and Providencia rettgeri. Pseudomonas species are generally resistant to the drug. Nalidixic acid is bactericidal and is effective over the entire urinary pH range. Conventional chromosomal resistance to nalidixic acid taken in full dosage has been reported to emerge in approximately 2 to 14 percent of patients during treatment; however, bacterial resistance to nalidixic acid has not been shown to be transferable via R factor.

Mebutan Absorption

Following oral administration, nalidixic acid is rapidly absorbed from the gastrointestinal tract. Bioavailability is approximately 96%. Absorption may be delayed if taken with antacids.

Mebutan side effects and Toxicity

ORAL (LD₅₀): Acute: 1160 mg/kg [Rat]. 572 mg/kg [Mouse]. Toxic psychosis, convulsions, increased intracranial pressure, or metabolic acidosis may occur in patients taking more than the recommended dosage. Vomiting, nausea, and lethargy may also occur following overdosage.

Mebutan Patient Information

Mebutan Organisms Affected

Enteric bacteria and other eubacteria