Midazolam
Midazolam Brand names, Midazolam Analogs
Midazolam Brand Names Mixture
- No information avaliable
Midazolam Chemical_Formula
C18H13ClFN3
Midazolam RX_link
http://www.rxlist.com/cgi/generic2/versedsyr.htm
Midazolam fda sheet
Midazolam msds (material safety sheet)
Midazolam Synthesis Reference
No information avaliable
Midazolam Molecular Weight
325.767 g/mol
Midazolam Melting Point
159 oC
Midazolam H2O Solubility
40.0 mg/ml
Midazolam State
Solid
Midazolam LogP
3.868
Midazolam Dosage Forms
Liquid; Solution
Midazolam Indication
For use in pediatric patients for sedation, anxiolysis, and amnesia prior to diagnostic, therapeutic, or endoscopic procedures or before induction of anesthesia.
Midazolam Pharmacology
Midazolam is a short-acting benzodiazepine central nervous system (CNS) depressant. Pharmacodynamic properties of midazolam and its metabolites, which are similar to those of other benzodiazepines, include sedative, anxiolytic, amnesic and hypnotic activities. Benzodiazepine pharmacologic effects appear to result from reversible interactions with the (gamma)-amino butyric acid (GABA) benzodiazepine receptor in the CNS, the major inhibitory neurotransmitter in the central nervous system. The action of midazolam is readily reversed by the benzodiazepine receptor antagonist, flumazenil.
Midazolam Absorption
Rapidly absorbed after oral administration (absolute bioavailability of the midazolam syrup in pediatric patients is about 36%, and intramuscular is greater than 90%).
Midazolam side effects and Toxicity
LD50=825 mg/kg (Orally in rats). Signs of overdose include sedation, somnolence, confusion, impaired coordination, diminished reflexes, coma, and deleterious effects on vital signs.
Midazolam Patient Information
Midazolam Organisms Affected
Humans and other mammals
