Midazolam
Brand names,
Midazolam
Analogs
Midazolam
Brand Names Mixture
Midazolam
Chemical_Formula
C18H13ClFN3
Midazolam
RX_link
http://www.rxlist.com/cgi/generic2/versedsyr.htm
Midazolam
fda sheet
Midazolam
msds (material safety sheet)
Midazolam
Synthesis Reference
No information avaliable
Midazolam
Molecular Weight
325.767 g/mol
Midazolam
Melting Point
159 oC
Midazolam
H2O Solubility
40.0 mg/ml
Midazolam
State
Solid
Midazolam
LogP
3.868
Midazolam
Dosage Forms
Liquid; Solution
Midazolam
Indication
For use in pediatric patients for sedation, anxiolysis, and amnesia prior to diagnostic, therapeutic, or endoscopic procedures or before induction of anesthesia.
Midazolam
Pharmacology
Midazolam is a short-acting benzodiazepine central nervous system (CNS) depressant. Pharmacodynamic properties of midazolam and its metabolites, which are similar to those of other benzodiazepines, include sedative, anxiolytic, amnesic and hypnotic activities. Benzodiazepine pharmacologic effects appear to result from reversible interactions with the (gamma)-amino butyric acid (GABA) benzodiazepine receptor in the CNS, the major inhibitory neurotransmitter in the central nervous system. The action of midazolam is readily reversed by the benzodiazepine receptor antagonist, flumazenil.
Midazolam
Absorption
Rapidly absorbed after oral administration (absolute bioavailability of the midazolam syrup in pediatric patients is about 36%, and intramuscular is greater than 90%).
Midazolam
side effects and Toxicity
LD50=825 mg/kg (Orally in rats). Signs of overdose include sedation, somnolence, confusion, impaired coordination, diminished reflexes, coma, and deleterious effects on vital signs.
Midazolam
Patient Information
Midazolam
Organisms Affected
Humans and other mammals