Midazolam Hcl
Midazolam Hcl Brand names, Midazolam Hcl Analogs
Midazolam Hcl Brand Names Mixture
- No information avaliable
Midazolam Hcl Chemical_Formula
C18H13ClFN3
Midazolam Hcl RX_link
http://www.rxlist.com/cgi/generic2/versedsyr.htm
Midazolam Hcl fda sheet
Midazolam Hcl msds (material safety sheet)
Midazolam Hcl Synthesis Reference
No information avaliable
Midazolam Hcl Molecular Weight
325.767 g/mol
Midazolam Hcl Melting Point
159 oC
Midazolam Hcl H2O Solubility
40.0 mg/ml
Midazolam Hcl State
Solid
Midazolam Hcl LogP
3.868
Midazolam Hcl Dosage Forms
Liquid; Solution
Midazolam Hcl Indication
For use in pediatric patients for sedation, anxiolysis, and amnesia prior to diagnostic, therapeutic, or endoscopic procedures or before induction of anesthesia.
Midazolam Hcl Pharmacology
Midazolam is a short-acting benzodiazepine central nervous system (CNS) depressant. Pharmacodynamic properties of midazolam and its metabolites, which are similar to those of other benzodiazepines, include sedative, anxiolytic, amnesic and hypnotic activities. Benzodiazepine pharmacologic effects appear to result from reversible interactions with the (gamma)-amino butyric acid (GABA) benzodiazepine receptor in the CNS, the major inhibitory neurotransmitter in the central nervous system. The action of midazolam is readily reversed by the benzodiazepine receptor antagonist, flumazenil.
Midazolam Hcl Absorption
Rapidly absorbed after oral administration (absolute bioavailability of the midazolam syrup in pediatric patients is about 36%, and intramuscular is greater than 90%).
Midazolam Hcl side effects and Toxicity
LD50=825 mg/kg (Orally in rats). Signs of overdose include sedation, somnolence, confusion, impaired coordination, diminished reflexes, coma, and deleterious effects on vital signs.
Midazolam Hcl Patient Information
Midazolam Hcl Organisms Affected
Humans and other mammals
