Lovasterol
Brand names,
Lovasterol
Analogs
Lovasterol
Brand Names Mixture
Lovasterol
Chemical_Formula
C24H36O5
Lovasterol
RX_link
http://www.rxlist.com/cgi/generic3/altocor.htm
Lovasterol
fda sheet
Lovasterol
msds (material safety sheet)
Lovasterol
Synthesis Reference
R. L. Monaghan et al., U.S. Pat. 4,231,938 (1980)
Lovasterol
Molecular Weight
404.54 g/mol
Lovasterol
Melting Point
174.5 oC
Lovasterol
H2O Solubility
0.0004 mg/mL
Lovasterol
State
Solid
Lovasterol
LogP
4
Lovasterol
Dosage Forms
Tablet
Lovasterol
Indication
For management as an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels in patients with primary hypercholesterolemia and mixed dyslipidemia; For primary prevention of coronary heart disease
Lovasterol
Pharmacology
Lovastatin, an antilipemic agent produced by fermentation of Aspergillus terreus, is the first of a class of lipid-lowering agents known as the HMG-CoA reductase inhibitors. Lovastatin is used to treat hypercholesterolemia, to slow coronary atherosclerosis, and to prevent myocardial infarction and stroke. Lovastatin, like simvastin and unlike pravastatin, is a prodrug, concentrating active drug in the liver during first-pass circulation.
Lovasterol
Absorption
30%
Lovasterol
side effects and Toxicity
LD50>1000 mg/kg (orally in mice)
Lovasterol
Patient Information
PATIENT INFORMATION
Lovastatin is used to lower high cholesterol levels. This medication should
not be taken if you are pregnant, nursing, or have liver disease. Lovastatin
should be taken with the evening meal. This medication may cause increased
sensitivity to sunlight. Use sunscreens and wear protective clothing until
degree of sensitivity is determined. Notify your physician if you develop
blurred vision; skin rash; muscle pain, weakness, or cramps; unexplained fever,
or yellowing of the skin or eyes.
Patients should be advised about substances they should not take concomitantly
with lovastatin and be advised to report promptly unexplained muscle pain,
tenderness, or weakness (see list below and WARNINGS, Myopathy/Rhabdomyolysis ).
Patients should also be advised to inform other physicians prescribing a new
medication that they are taking MEVACOR .
Lovasterol
Organisms Affected
Humans and other mammals