Lotrimin Af

Lotrimin Af Brand names, Lotrimin Af Analogs

Lotrimin Af Brand Names Mixture

Lotrisone (clotrimazole + betamethasone)

Lotrimin Af Chemical_Formula

C₂₂H₁₇ClN₂

Lotrimin Af RX_link

http://www.rxlist.com/cgi/generic2/clotrimaz.htm

Lotrimin Af fda sheet

Lotrimin_Af FDA

Lotrimin Af msds (material safety sheet)

Lotrimin_Af MSDS

Lotrimin Af Synthesis Reference

K. H. Buechel et al.; U.S. Pat. 4,705,172(1972)

Lotrimin Af Molecular Weight

344.837 g/mol

Lotrimin Af Melting Point

147-149 ^oC

Lotrimin Af H₂O Solubility

29.84 mg/mL

Lotrimin Af State

Solid

Lotrimin Af LogP

5.98

Lotrimin Af Dosage Forms

Cream; Liquid; Solution; Suppository; Ointment; Lozenge

Lotrimin Af Indication

For the local treatment of oropharyngeal candidiasis and vaginal yeast infections, also used in fungal infections of the skin such as ringworm, athlete's foot, and jock itch.

Lotrimin Af Pharmacology

Clotrimazole, an imidazole derivative with a broad spectrum of antimycotic activity, inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. Betamethasone and clotrimazole are used together to treat cutaneous tinea infections. In studies in fungal cultures, the minimum fungicidal concentration of clotrimazole caused leakage of intracellular phosphorous compounds into the ambient medium with concomitant breakdown of cellular nucleic acids, and accelerated potassium etflux. Both of these events began rapidly and extensively after addition of the drug to the cultures. The primary action of clotrimazole is against dividing and growing organisms.

Lotrimin Af Absorption

Poorly and erratically absorbed orally, minimal vaginal or topical absorption.

Lotrimin Af side effects and Toxicity

Symptoms of overdose include erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning, and general irritation of the skin, and cramps.

Lotrimin Af Patient Information

How to use Clotrimazole :Use clotrimazole exactly as directed by your doctor. Always
read the manufacturer's information leaflet, if possible, before beginning treatment.
Clotrimazole preparations are usually applied two to three times a day until the
infection has cleared. This medicine is for you. Never give it to others, even if
their condition appears to be the same as yours. Getting the most from your
treatment : Always wash and dry your hands thoroughly before and after handling
clotrimazole. Do not allow clotrimazole to come into contact with the eyes, ears,
or mucous membranes (eg. mouth, vagina, inside of nose etc.), unless you are advised
to do so by your doctor. Complete the full course of treatment with clotrimazole,
otherwise your infection is likely to recur. Before using any 'over-the-counter'
medicines, check with your pharmacist which medicines are safe for you to use alongside
clotrimazole. You should see an improvement in your condition after a few days.
If your condition does not seem to be getting better after seven days, consult your
doctor for advice.

Lotrimin Af Organisms Affected

Yeast and other fungi